Baseline characteristics of 81 patients with CNS aspergillosis treated with voriconazole
. | Data . |
|---|---|
| Total no. of patients | 81 |
| Definite diagnosis, no. (%) | 48 (59) |
| Probable diagnosis, no. (%) | 33 (41) |
| Age | |
| Median | 43 y |
| Range | 9 mo-81 y |
| Sex, no. | |
| Male | 47 |
| Female | 34 |
| Antifungal pretreatment, no. (%) | 78 (96) |
| Duration | |
| Median | 31 d |
| Range | 2 d-88 mo |
| Agent, no. | |
| Amphotericin B (or lipid derivatives) | 76 |
| Itraconazole | 37 |
| 5-fluorocytosine | 22 |
| Caspofungin | 5 |
| Underlying conditions, no. (%) | |
| Hematopoietic stem cell transplantation | 32 (39) |
| Hematologic malignancy | 13 (16) |
| Solid organ transplantation | 11 (14) |
| Chronic immunosuppression | 11 (14) |
| Other* | 14 (17) |
. | Data . |
|---|---|
| Total no. of patients | 81 |
| Definite diagnosis, no. (%) | 48 (59) |
| Probable diagnosis, no. (%) | 33 (41) |
| Age | |
| Median | 43 y |
| Range | 9 mo-81 y |
| Sex, no. | |
| Male | 47 |
| Female | 34 |
| Antifungal pretreatment, no. (%) | 78 (96) |
| Duration | |
| Median | 31 d |
| Range | 2 d-88 mo |
| Agent, no. | |
| Amphotericin B (or lipid derivatives) | 76 |
| Itraconazole | 37 |
| 5-fluorocytosine | 22 |
| Caspofungin | 5 |
| Underlying conditions, no. (%) | |
| Hematopoietic stem cell transplantation | 32 (39) |
| Hematologic malignancy | 13 (16) |
| Solid organ transplantation | 11 (14) |
| Chronic immunosuppression | 11 (14) |
| Other* | 14 (17) |
Other underlying diseases/conditions: having just had surgery (n = 2), trauma (n = 2), renal insufficiency (n = 2), polyradiculopathy (n = 1), liver cirrhosis (n = 1), tuberculosis (n = 1), obstructive pulmonary disease (n = 1), chronic sinusitis (n = 1), and unknown (n = 3).