Table 1.

IDO expression and activity



IDO mRNA (qPCR)*

IDO activity (μM kynurenine, HPLC)
Conditions
n
Average
Range
SEM
n
Average
Range
SEM
iDC   7   0.017   0.09-0.06   0.007   6   4.3   2.8-7.7   0.8  
TNFα + PGE2  7   3.3   1.01-8.17   1.01   6   38   19.3-68.9   7.6  
LPS   4   0.24   0.09-0.39   0.06   3   7.6   2.8-14   3.3  
SAC   3   0.05   0-0.13   0.04   1   4.3   N/A   N/A  
TNFα + PGE2 + IFN-γ
 
1
 
5.1
 
N/A
 
N/A
 
3
 
66.5
 
60.4-74
 
4.0
 


IDO mRNA (qPCR)*

IDO activity (μM kynurenine, HPLC)
Conditions
n
Average
Range
SEM
n
Average
Range
SEM
iDC   7   0.017   0.09-0.06   0.007   6   4.3   2.8-7.7   0.8  
TNFα + PGE2  7   3.3   1.01-8.17   1.01   6   38   19.3-68.9   7.6  
LPS   4   0.24   0.09-0.39   0.06   3   7.6   2.8-14   3.3  
SAC   3   0.05   0-0.13   0.04   1   4.3   N/A   N/A  
TNFα + PGE2 + IFN-γ
 
1
 
5.1
 
N/A
 
N/A
 
3
 
66.5
 
60.4-74
 
4.0
 

N/A indicates not applicable.

*

Reported as a ratio of relative mRNA expression IDO/GAPDH. Non-normalized data are presented

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