Frequency and types of mutations detected according to disease phase
. | Accelerated phase, no. (%) . | Myeloid blast crisis, no. (%) . | Total, no. (%) . |
|---|---|---|---|
| No. patients | 27 | 19 | NA |
| Q252H | 1 | 0 | 1 (1.5) |
| Y253F | 1 | 1 | 2 (3.0) |
| Y253H | 1 | 1 | 2 (3.0) |
| E255K | 0 | 0 | 0 (0) |
| E255V | 0 | 0 | 0 (0) |
| T315I | 7 | 1 | 8 (12.1) |
| M351T | 0 | 0 | 0 (0) |
| F359V | 0 | 1 | 1 (1.5) |
| V289I* | 0 | 1 | 1 (1.5) |
| Total (% of patients) | 10 (37.0) | 5 (23.8) | NA |
. | Accelerated phase, no. (%) . | Myeloid blast crisis, no. (%) . | Total, no. (%) . |
|---|---|---|---|
| No. patients | 27 | 19 | NA |
| Q252H | 1 | 0 | 1 (1.5) |
| Y253F | 1 | 1 | 2 (3.0) |
| Y253H | 1 | 1 | 2 (3.0) |
| E255K | 0 | 0 | 0 (0) |
| E255V | 0 | 0 | 0 (0) |
| T315I | 7 | 1 | 8 (12.1) |
| M351T | 0 | 0 | 0 (0) |
| F359V | 0 | 1 | 1 (1.5) |
| V289I* | 0 | 1 | 1 (1.5) |
| Total (% of patients) | 10 (37.0) | 5 (23.8) | NA |
No mutations were detected in the 20 patients with chronic-phase disease.
NA indicates not applicable
This mutation was not included in the ASO-PCR assay and was detected by sequencing.