Biomarkers in follicular lymphoma
Biomarker . | No. failed . | No. positive (%) . | Morphologic pattern . | OS P . | Comments . |
|---|---|---|---|---|---|
| Bcl-2 | 2 | 92 (89) | — | NS | |
| Bcl-XL | 1 | 15 (14) | — | NS | >10% lymphoma cells |
| Bcl-6 | 1 | 81 (78) | — | NS | |
| CD10 | 2 | 94 (91) | — | NS | |
| Interfollicular CD10 | 2 | 78 (76) | — | NS | Presence of interfollicular CD10+ neoplastic cells |
| Ki-67 (MIB-1) | 5 | 62 (62) | — | NS | > 50% neoplastic nuclei |
| CD4 | 2 | 78 (76) | — | NS | Majority of T cells |
| CD7 pattern | 1 | 73 (70) | Interfollicular | NS | Interfollicular CD7 predominance |
| CD4/CD8 pattern | 5 | 71 (71) | Follicular | NS | Intrafollicular CD4 and perifollicular CD8 |
| FDC (CD21) pattern | 19 | 27 (31) | Expanded follicles | NS | Coalescence of FDC meshwork |
| CD57 | 1 | 67 (64) | — | NS | >10% of T cells |
| CD57 pattern | 13 | 68 (63) | Follicular | NS | Intrafollicular CD57 predominance |
| TIA-1 | 1 | 47 (45) | — | NS | >10% of T cells |
| CD68+ macrophages | 6 | 12 (12) | — | <.001 | >15 macrophages/hpf (X 1 000) |
Biomarker . | No. failed . | No. positive (%) . | Morphologic pattern . | OS P . | Comments . |
|---|---|---|---|---|---|
| Bcl-2 | 2 | 92 (89) | — | NS | |
| Bcl-XL | 1 | 15 (14) | — | NS | >10% lymphoma cells |
| Bcl-6 | 1 | 81 (78) | — | NS | |
| CD10 | 2 | 94 (91) | — | NS | |
| Interfollicular CD10 | 2 | 78 (76) | — | NS | Presence of interfollicular CD10+ neoplastic cells |
| Ki-67 (MIB-1) | 5 | 62 (62) | — | NS | > 50% neoplastic nuclei |
| CD4 | 2 | 78 (76) | — | NS | Majority of T cells |
| CD7 pattern | 1 | 73 (70) | Interfollicular | NS | Interfollicular CD7 predominance |
| CD4/CD8 pattern | 5 | 71 (71) | Follicular | NS | Intrafollicular CD4 and perifollicular CD8 |
| FDC (CD21) pattern | 19 | 27 (31) | Expanded follicles | NS | Coalescence of FDC meshwork |
| CD57 | 1 | 67 (64) | — | NS | >10% of T cells |
| CD57 pattern | 13 | 68 (63) | Follicular | NS | Intrafollicular CD57 predominance |
| TIA-1 | 1 | 47 (45) | — | NS | >10% of T cells |
| CD68+ macrophages | 6 | 12 (12) | — | <.001 | >15 macrophages/hpf (X 1 000) |
—indicates not evaluated; NS, not significant.