Characteristics of patient samples used in this study
Patient no. . | Sex/age, y . | Rai/Binet staging . | Lymphocyte count, × 109/L . | ZAP-70 expression, % . | IgVH homology . | 17-AAG-induced apoptosis, % . | % Active Hsp90 . | Number of previous treatments . |
|---|---|---|---|---|---|---|---|---|
| 1 | M/64 | 2/A | 419 | 0.4 | Mutated | 3.9 | 27.7 | 2 |
| 2 | M/58 | 2/A | 66 | 0.4 | Mutated | 4.5 | 8.8 | 0 |
| 3 | M/43 | 2/A | 62 | 0.6 | Mutated | 1.2 | 12 | 0 |
| 4 | F/67 | 2/A | 18 | 0.8 | Unmutated | 4.7 | 27.5 | 0 |
| 5 | M/50 | 2/B | 193 | 1.5 | Mutated | 11.5 | 0 | 2 |
| 6 | M/75 | 2/A | 25 | 2.0 | Mutated | 12.3 | 0 | 0 |
| 7 | F/65 | 2/A | 74 | 6.3 | Mutated | 14.9 | 10.4 | 2 |
| 8 | F/62 | 2/A | 109 | 6.8 | Mutated | 3.7 | ND | 0 |
| 9 | F/63 | 1/A | 85 | 9.4 | Unmutated | 0.5 | ND | 1 |
| 10 | F/59 | 1/A | 112 | 10.6 | Mutated | 12.6 | ND | 0 |
| 11 | F/60 | 3/C | 96 | 12.3 | Mutated | 3.4 | 4.1 | 5 |
| 12 | F/55 | 2/B | 240 | 18.8 | Unmutated | 22.4 | ND | 2 |
| 13 | M/59 | 3/C | 55 | 20.3 | Mutated | 55.4 | ND | 1 |
| 14 | M/77 | 2/B | 101 | 29.1 | Unmutated | 33.9 | 100 | 0 |
| 15 | F/67 | 2/A | 560 | 29.1 | Unmutated | 37.9 | ND | 2 |
| 16 | M/67 | 2/A | 60 | 43.2 | Unmutated | 35.4 | 100 | 2 |
| 17 | F/60 | 2/A | 68 | 54.6 | Unmutated | 41.3 | 99 | 2 |
| 18 | F/48 | 1/A | 9 | 59.0 | Unmutated | 57.9 | 99 | 1 |
| 19 | M/67 | 4/C | 60 | 67.1 | Unmutated | 57.7 | ND | 2 |
| 20 | F/61 | 1/A | 33 | 81.9 | Unmutated | 67.4 | 99 | 0 |
| 21 | M/50 | 2/A | 89 | 85.5 | Unmutated | 69.4 | 100 | 1 |
| 22 | F/49 | 4/C | 57 | 87.1 | Unmutated | 66.8 | 100 | 4 |
| 23 | F/75 | 2/A | 61 | 90.5 | Unmutated | 78.8 | ND | 0 |
| 24 | M/70 | 2/A | 93 | 91.1 | Unmutated | 79.9 | ND | 0 |
| 25 | F/54 | 1/A | 32 | 91.9 | Unmutated | 74.4 | 99 | 0 |
Patient no. . | Sex/age, y . | Rai/Binet staging . | Lymphocyte count, × 109/L . | ZAP-70 expression, % . | IgVH homology . | 17-AAG-induced apoptosis, % . | % Active Hsp90 . | Number of previous treatments . |
|---|---|---|---|---|---|---|---|---|
| 1 | M/64 | 2/A | 419 | 0.4 | Mutated | 3.9 | 27.7 | 2 |
| 2 | M/58 | 2/A | 66 | 0.4 | Mutated | 4.5 | 8.8 | 0 |
| 3 | M/43 | 2/A | 62 | 0.6 | Mutated | 1.2 | 12 | 0 |
| 4 | F/67 | 2/A | 18 | 0.8 | Unmutated | 4.7 | 27.5 | 0 |
| 5 | M/50 | 2/B | 193 | 1.5 | Mutated | 11.5 | 0 | 2 |
| 6 | M/75 | 2/A | 25 | 2.0 | Mutated | 12.3 | 0 | 0 |
| 7 | F/65 | 2/A | 74 | 6.3 | Mutated | 14.9 | 10.4 | 2 |
| 8 | F/62 | 2/A | 109 | 6.8 | Mutated | 3.7 | ND | 0 |
| 9 | F/63 | 1/A | 85 | 9.4 | Unmutated | 0.5 | ND | 1 |
| 10 | F/59 | 1/A | 112 | 10.6 | Mutated | 12.6 | ND | 0 |
| 11 | F/60 | 3/C | 96 | 12.3 | Mutated | 3.4 | 4.1 | 5 |
| 12 | F/55 | 2/B | 240 | 18.8 | Unmutated | 22.4 | ND | 2 |
| 13 | M/59 | 3/C | 55 | 20.3 | Mutated | 55.4 | ND | 1 |
| 14 | M/77 | 2/B | 101 | 29.1 | Unmutated | 33.9 | 100 | 0 |
| 15 | F/67 | 2/A | 560 | 29.1 | Unmutated | 37.9 | ND | 2 |
| 16 | M/67 | 2/A | 60 | 43.2 | Unmutated | 35.4 | 100 | 2 |
| 17 | F/60 | 2/A | 68 | 54.6 | Unmutated | 41.3 | 99 | 2 |
| 18 | F/48 | 1/A | 9 | 59.0 | Unmutated | 57.9 | 99 | 1 |
| 19 | M/67 | 4/C | 60 | 67.1 | Unmutated | 57.7 | ND | 2 |
| 20 | F/61 | 1/A | 33 | 81.9 | Unmutated | 67.4 | 99 | 0 |
| 21 | M/50 | 2/A | 89 | 85.5 | Unmutated | 69.4 | 100 | 1 |
| 22 | F/49 | 4/C | 57 | 87.1 | Unmutated | 66.8 | 100 | 4 |
| 23 | F/75 | 2/A | 61 | 90.5 | Unmutated | 78.8 | ND | 0 |
| 24 | M/70 | 2/A | 93 | 91.1 | Unmutated | 79.9 | ND | 0 |
| 25 | F/54 | 1/A | 32 | 91.9 | Unmutated | 74.4 | 99 | 0 |
ND indicates no data.