Summary of results from secondary transplantation experiments using lymphoid tissues: lymphoid cells from MSCV-Myc mice are not fully transformed
Donor leukemic mice . | Tissue . | Recipients affected . | Mean survival, days . | Disease phenotype . |
|---|---|---|---|---|
| Myc→Ink4a+/+ | Thymocytes | 3/3 | 34 | Myeloid leukemia |
| MIB→BALB/c | Thymocytes | 2/2 | 58 | Mixed-lineage leukemia |
| MIB→BALB/c | LN cells | 3/3 | 37 | Mixed-lineage leukemia |
| Myc→BALB/c | LN cells | 0/2 | NA | None |
Donor leukemic mice . | Tissue . | Recipients affected . | Mean survival, days . | Disease phenotype . |
|---|---|---|---|---|
| Myc→Ink4a+/+ | Thymocytes | 3/3 | 34 | Myeloid leukemia |
| MIB→BALB/c | Thymocytes | 2/2 | 58 | Mixed-lineage leukemia |
| MIB→BALB/c | LN cells | 3/3 | 37 | Mixed-lineage leukemia |
| Myc→BALB/c | LN cells | 0/2 | NA | None |
Single-cell suspensions containing 1 × 106 to 2 × 106 cells from indicated tissues of moribund primary animals were injected intravenously into sublethally irradiated syngeneic mice.
Myc indicates MSCV-Myc; MIB, MSCV-Myc + Bcl2; LN, lymph node; NA, not achieved.