Mean arterial pressure, leukocyte count, blood flow, and vessel diameter in test rats
. | Mean arterial pressure, mm Hg . | . | Leukocyte count, × 199/L . | . | Mean blood flow, mm/sec . | . | Vessel diameter, μm . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | Base . | 90 min . | PMN . | PBMC . | Base . | 60 min . | . | |||
| Active immunization | ||||||||||
| EAV | 105.6 ± 3.9 | 109.8 ± 5.8 | 1.5 ± 0.1 | 5.7 ± 0.5 | 1.1 ± 0.1 | 1.8 ± 0.2 | 28.7 ± 0.4 | |||
| Control | 103.4 ± 2.6 | 106.9 ± 3.0 | 1.2 ± 0.2 | 5.8 ± 0.7 | 1.5 ± 0.3 | 2.1 ± 0.4 | 28.0 ± 0.4 | |||
| Passive transfer | ||||||||||
| ANCA+ | 105.4 ± 3.0 | 121.4 ± 3.7 | 1.0 ± 0.1 | 4.1 ± 0.4 | ND | 3.4 ± 0.6 | 30.3 ± 0.7 | |||
| ANCA− | 106.0 ± 3.8 | 118.3 ± 2.7 | 1.3 ± 0.3 | 4.0 ± 0.4 | ND | 3.1 ± 0.4 | 30.0 ± 0.6 | |||
. | Mean arterial pressure, mm Hg . | . | Leukocyte count, × 199/L . | . | Mean blood flow, mm/sec . | . | Vessel diameter, μm . | |||
|---|---|---|---|---|---|---|---|---|---|---|
. | Base . | 90 min . | PMN . | PBMC . | Base . | 60 min . | . | |||
| Active immunization | ||||||||||
| EAV | 105.6 ± 3.9 | 109.8 ± 5.8 | 1.5 ± 0.1 | 5.7 ± 0.5 | 1.1 ± 0.1 | 1.8 ± 0.2 | 28.7 ± 0.4 | |||
| Control | 103.4 ± 2.6 | 106.9 ± 3.0 | 1.2 ± 0.2 | 5.8 ± 0.7 | 1.5 ± 0.3 | 2.1 ± 0.4 | 28.0 ± 0.4 | |||
| Passive transfer | ||||||||||
| ANCA+ | 105.4 ± 3.0 | 121.4 ± 3.7 | 1.0 ± 0.1 | 4.1 ± 0.4 | ND | 3.4 ± 0.6 | 30.3 ± 0.7 | |||
| ANCA− | 106.0 ± 3.8 | 118.3 ± 2.7 | 1.3 ± 0.3 | 4.0 ± 0.4 | ND | 3.1 ± 0.4 | 30.0 ± 0.6 | |||
WKY rats were immunized (“Active immunization”) with hMPO (EAV, n = 7-20 per group) or HSA (Control, n = 8-18 per group) in CFA, or received lg (“Passive transfer”; ANCA+, n = 9, ANCA−, n = 9). No significant differences between the groups within each experiment were observed. Values are mean ± SEM.
ND indicates not done.