Chemokine receptors expressed by NK cells and DCs
. | CCR1 . | CCR2 . | CCR3 . | CCR4 . | CCR5 . | CCR6 . | CCR7 . | CCR8 . | CCR9 . | CXCR1 . | CXCR2 . | CXCR3 . | CXCR4 . | CXCR5 . | CX3CR1 . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Human NK cells | |||||||||||||||
| Resting CD56dim NK cells | – | – | – | + | – | – | – | – | – | +++ | ND | ++ | +++ | – | +++ |
| Resting CD56bright NK cells | – | – | – | – | ++ | +/– | ++ | – | – | + | ND | +++ | +++ | – | +/– |
| Activated NK cells | – | +/– | – | ++ | – | + | +/– | – | ND | – | ND | +++ | + | – | + |
| Mouse NK cells | |||||||||||||||
| Resting | (–) | (++) | (–) | (–) | +++ | – | (–) | (–) | (–) | ND | ND | +++ | +++ | – | (+) |
| Human DCs* | |||||||||||||||
| Immature | + | +/– | ND | + | + | + | +/– | ND | ND | ND | ND | ND | + | – | ND |
| Mature | – | – | ND | + | – | – | ++ | ND | ND | ND | ND | ND | ++ | – | ND |
| Mouse DCs† | |||||||||||||||
| Immature | +++ | + | – | +/– | + | ND | – | ND | ND | ND | – | ND | + | – | ND |
| Mature | + | – | – | – | – | ND | ++ | ND | ND | ND | – | ND | + | – | ND |
. | CCR1 . | CCR2 . | CCR3 . | CCR4 . | CCR5 . | CCR6 . | CCR7 . | CCR8 . | CCR9 . | CXCR1 . | CXCR2 . | CXCR3 . | CXCR4 . | CXCR5 . | CX3CR1 . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Human NK cells | |||||||||||||||
| Resting CD56dim NK cells | – | – | – | + | – | – | – | – | – | +++ | ND | ++ | +++ | – | +++ |
| Resting CD56bright NK cells | – | – | – | – | ++ | +/– | ++ | – | – | + | ND | +++ | +++ | – | +/– |
| Activated NK cells | – | +/– | – | ++ | – | + | +/– | – | ND | – | ND | +++ | + | – | + |
| Mouse NK cells | |||||||||||||||
| Resting | (–) | (++) | (–) | (–) | +++ | – | (–) | (–) | (–) | ND | ND | +++ | +++ | – | (+) |
| Human DCs* | |||||||||||||||
| Immature | + | +/– | ND | + | + | + | +/– | ND | ND | ND | ND | ND | + | – | ND |
| Mature | – | – | ND | + | – | – | ++ | ND | ND | ND | ND | ND | ++ | – | ND |
| Mouse DCs† | |||||||||||||||
| Immature | +++ | + | – | +/– | + | ND | – | ND | ND | ND | – | ND | + | – | ND |
| Mature | + | – | – | – | – | ND | ++ | ND | ND | ND | – | ND | + | – | ND |
Symbols in parentheses indicate a demonstrated activity of the corresponding receptor using in vitro chemotaxis assays. Based on Sozzani et al,35 Campbell et al,81 Hanna et al,82 Inngjerdingen et al,83 and Vecchi et al.84
ND indicates not determined; +, detectable; ++, intermediate expression; +++, high expression; +/–, low-to-undetectable expression; and –, undetectable expression.
Monocyte-derived DCs
Bone marrow–derived DCs