Table 1. Effect of TLR activation upon... | American Society of Hematology

Table 1.

Effect of TLR activation upon 11β-HSD1 reductase activity of monocyte-derived DCs

Agonist^*	TLR	Reductase activity, ratio of agonist to control, pmoles/h/10⁶ cells†	P³‡
Pam₃CSK₄	TLR1/2	2.32 ± 0.28	.07
Zymosan	TLR2/6	2.85 ± 0.83	< .001
Poly I:C	TLR3	1.75 ± 0.53§	NS
LPS	TLR4	1.31 ± 0.27	NS
Flagellin	TLR5	2.27 ± 0.48	< .05

Agonist^*	TLR	Reductase activity, ratio of agonist to control, pmoles/h/10⁶ cells†	P³‡
Pam₃CSK₄	TLR1/2	2.32 ± 0.28	.07
Zymosan	TLR2/6	2.85 ± 0.83	< .001
Poly I:C	TLR3	1.75 ± 0.53§	NS
LPS	TLR4	1.31 ± 0.27	NS
Flagellin	TLR5	2.27 ± 0.48	< .05

NS indicates not significant.

n = 5 independent experiments for all agonists, except LPS, for which n = 3 independent experiments

Mean ± SEM ratio of activity of agonist to control, measured in pmoles/h/10⁶ cells

Paired t test

Comparison to poly dI:dC control