RAS mutation status by French-American-British (FAB) subtype
. | NRAS . | . | KRAS . | . | ||
|---|---|---|---|---|---|---|
| FAB type . | Mutant, no. (%) . | Nonmutant, no. (%) . | Mutant, no. (%) . | Nonmutant, no. (%) . | ||
| AML M0 | 4 (3) | 20 (2) | 2 (5) | 12 (2) | ||
| AML M1 | 20 (16) | 159 (17) | 0 (0) | 108 (16) | ||
| AML M2 | 31 (25) | 254 (28) | 9 (24) | 187 (29) | ||
| AML M3 | 11 (9) | 170 (19) | 5 (13) | 129 (20) | ||
| AML M4 | 38 (30) | 173 (19) | 19 (50) | 131 (20) | ||
| AML M5 | 18 (14) | 87 (10) | 2 (5) | 59 (9) | ||
| AML M6 | 2 (2) | 19 (2) | 0 (0) | 13 (2) | ||
| AML M7 | 0 (0) | 11 (1) | 0 (0) | 7 (1) | ||
| RAEB | 2 (2) | 10 (1) | 1 (3) | 6 (1) | ||
| Bilineage | 0 (0) | 1 (< 0.5) | 0 (0) | 0 (0) | ||
| ALL | 0 (0) | 6 (1) | 0 (0) | 4 (1) | ||
| Other | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Total with known FAB type | 126 (100) | 910 (100) | 38 (100) | 656 (100) | ||
| Unknown/unclassified | 0 (0) | 70 (8) | 1 (3) | 44 (7) | ||
. | NRAS . | . | KRAS . | . | ||
|---|---|---|---|---|---|---|
| FAB type . | Mutant, no. (%) . | Nonmutant, no. (%) . | Mutant, no. (%) . | Nonmutant, no. (%) . | ||
| AML M0 | 4 (3) | 20 (2) | 2 (5) | 12 (2) | ||
| AML M1 | 20 (16) | 159 (17) | 0 (0) | 108 (16) | ||
| AML M2 | 31 (25) | 254 (28) | 9 (24) | 187 (29) | ||
| AML M3 | 11 (9) | 170 (19) | 5 (13) | 129 (20) | ||
| AML M4 | 38 (30) | 173 (19) | 19 (50) | 131 (20) | ||
| AML M5 | 18 (14) | 87 (10) | 2 (5) | 59 (9) | ||
| AML M6 | 2 (2) | 19 (2) | 0 (0) | 13 (2) | ||
| AML M7 | 0 (0) | 11 (1) | 0 (0) | 7 (1) | ||
| RAEB | 2 (2) | 10 (1) | 1 (3) | 6 (1) | ||
| Bilineage | 0 (0) | 1 (< 0.5) | 0 (0) | 0 (0) | ||
| ALL | 0 (0) | 6 (1) | 0 (0) | 4 (1) | ||
| Other | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Total with known FAB type | 126 (100) | 910 (100) | 38 (100) | 656 (100) | ||
| Unknown/unclassified | 0 (0) | 70 (8) | 1 (3) | 44 (7) | ||
Percentages are percentages of those with known FAB type. P = .04 for NRAS; P = .001 for KRAS. P values for those with known FAB type only. RAEB indicates refractory anemia with excess of blasts; ALL, acute lymphoblastic leukemia.