B- and C-findings.
| B-Findings = | Indication of high burden of MCs, and expansion of the genetic defect into various myeloid lineages without impairment of organ function B = Borderline Benign |
| 1. | Infiltration grade (MCs) in bone marrow > 30% in histology and serum total tryptase level > 200 ng/mL |
| 2. | Hypercellular marrow with loss of fat cells, discrete signs of dysmyelopoiesis without substantial cytopenias or WHO criteria for an MDS or MPD |
| 3. | Organomegaly: palpable hepatomegaly, splenomegaly, or lymphadenopathy (on CT or US: > 2 cm) without impaired organ function |
| C-Findings = | Indication of impaired organ function due to MC infiltration (has to be confirmed by biopsy in most cases) C = Consider Cytoreduction |
| 1. | Cytopenia(s): ANC < 1000/μL or Hb < 10 g/dL or Plt < 100,000/μL |
| 2. | Hepatomegaly with ascites and impaired liver function |
| 3. | Palpable splenomegaly with hypersplenism |
| 4. | Malabsorption with hypoalbuminemia and weight loss |
| 5. | Skeletal lesions: large-sized osteolyses or/and severe osteoporosis causing pathologic fractures |
| 6. | Life-threatening organopathy in other organ systems that is definitively caused by an infiltration of the tissue by neoplastic MCs |
| B-Findings = | Indication of high burden of MCs, and expansion of the genetic defect into various myeloid lineages without impairment of organ function B = Borderline Benign |
| 1. | Infiltration grade (MCs) in bone marrow > 30% in histology and serum total tryptase level > 200 ng/mL |
| 2. | Hypercellular marrow with loss of fat cells, discrete signs of dysmyelopoiesis without substantial cytopenias or WHO criteria for an MDS or MPD |
| 3. | Organomegaly: palpable hepatomegaly, splenomegaly, or lymphadenopathy (on CT or US: > 2 cm) without impaired organ function |
| C-Findings = | Indication of impaired organ function due to MC infiltration (has to be confirmed by biopsy in most cases) C = Consider Cytoreduction |
| 1. | Cytopenia(s): ANC < 1000/μL or Hb < 10 g/dL or Plt < 100,000/μL |
| 2. | Hepatomegaly with ascites and impaired liver function |
| 3. | Palpable splenomegaly with hypersplenism |
| 4. | Malabsorption with hypoalbuminemia and weight loss |
| 5. | Skeletal lesions: large-sized osteolyses or/and severe osteoporosis causing pathologic fractures |
| 6. | Life-threatening organopathy in other organ systems that is definitively caused by an infiltration of the tissue by neoplastic MCs |