Table 2.

Summary of novel antileukemic agents being evaluated in chronic myeloid leukemia (CML).a

AgentMolecular mechanism(s)Ref.
* See text for further details. 
** Data not yet published 
a Modified from
Druker BJ.
Semin Hematol
.
2003
;
40
:
50
–58.
 
Abbreviations: As2O3, arsenic trioxide; hsp90, heat-shock protein 90; PS341, proteasome inhibitor 341; MAPK, mitogen-activated protein kinase; PI3-kinase, phosphatidylinositol-3-kinase; 17-AAG, allylamino-17-demethoxygeldanamycin; TRAIL, tumor necrosis factor α-related apoptosis-inducing ligand. 
17-AAG hsp90 chaperone function inhibition 35  
Adaphostin Tyrosine kinase inhibition 36  
AG490 Tyrosine kinase inhibition 37  
AMN107* Abl kinase inhibitor ** 
AP23464 Abl & src kinase inhibitor 38  
As2O3 Induction of mitochondrial damage,
 Bcr-Abl downregulation 39,40  
Bestatin, actinonin Aminopeptidase inhibition 41  
BMS354825* Abl & src kinase inhibitor 34  
Decitabine DNA hypomethylation 42  
Homoharringtonine Inhibition of protein synthesis 43  
Leptomycin Nuclear entrapment of Bcr-Abl 44  
PD184352 MAPK kinase inhibition 45  
Wortmannin, LY294002 PI3-kinase inhibition 46,47  
PS341 Proteasome inhibition 48  
SCH66336, L-744,832 Farnesyl transferase inhibition 35,49,50  
TRAIL Induction of apoptosis 51  
Trichostatin A Histone deacetylase inhibition 42  
AgentMolecular mechanism(s)Ref.
* See text for further details. 
** Data not yet published 
a Modified from
Druker BJ.
Semin Hematol
.
2003
;
40
:
50
–58.
 
Abbreviations: As2O3, arsenic trioxide; hsp90, heat-shock protein 90; PS341, proteasome inhibitor 341; MAPK, mitogen-activated protein kinase; PI3-kinase, phosphatidylinositol-3-kinase; 17-AAG, allylamino-17-demethoxygeldanamycin; TRAIL, tumor necrosis factor α-related apoptosis-inducing ligand. 
17-AAG hsp90 chaperone function inhibition 35  
Adaphostin Tyrosine kinase inhibition 36  
AG490 Tyrosine kinase inhibition 37  
AMN107* Abl kinase inhibitor ** 
AP23464 Abl & src kinase inhibitor 38  
As2O3 Induction of mitochondrial damage,
 Bcr-Abl downregulation 39,40  
Bestatin, actinonin Aminopeptidase inhibition 41  
BMS354825* Abl & src kinase inhibitor 34  
Decitabine DNA hypomethylation 42  
Homoharringtonine Inhibition of protein synthesis 43  
Leptomycin Nuclear entrapment of Bcr-Abl 44  
PD184352 MAPK kinase inhibition 45  
Wortmannin, LY294002 PI3-kinase inhibition 46,47  
PS341 Proteasome inhibition 48  
SCH66336, L-744,832 Farnesyl transferase inhibition 35,49,50  
TRAIL Induction of apoptosis 51  
Trichostatin A Histone deacetylase inhibition 42  
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