Summary of clinical features contrasting and comparing overt strokes and silent cerebral infarcts.
| . | Overt Strokes . | Silent Cerebral Infarcts . |
|---|---|---|
| *The 9% and 22% risk of infarct and silent cerebral infarct are not mutually exclusive. The incidence of silent cerebral infarcts excludes patients who had an overt stroke; however, patients with an overt stroke may have had silent cerebral infarcts. | ||
| Abbreviations: TCD, transcranial Doppler; SIT, silent cerebral infarct transfusion | ||
| Frequency prior to 14th birthday | 9%23 | 22%4 |
| Average age of onset | 7.7 years23 | Prior to 6 years of age6 |
| Wechsler Intelligent Scale for Children-Revised, Full Scale Intelligence Quotient | 70.81 | 82.81 |
| Role of Transcranial Doppler | Associated with an abnormal TCD velocity12 | Not necessarily associated with an abnormal TCD velocity24 |
| Treatment | Blood transfusion therapy to keep hemoglobin S less than 30%7 | No established treatment Focus of SIT Trial |
| . | Overt Strokes . | Silent Cerebral Infarcts . |
|---|---|---|
| *The 9% and 22% risk of infarct and silent cerebral infarct are not mutually exclusive. The incidence of silent cerebral infarcts excludes patients who had an overt stroke; however, patients with an overt stroke may have had silent cerebral infarcts. | ||
| Abbreviations: TCD, transcranial Doppler; SIT, silent cerebral infarct transfusion | ||
| Frequency prior to 14th birthday | 9%23 | 22%4 |
| Average age of onset | 7.7 years23 | Prior to 6 years of age6 |
| Wechsler Intelligent Scale for Children-Revised, Full Scale Intelligence Quotient | 70.81 | 82.81 |
| Role of Transcranial Doppler | Associated with an abnormal TCD velocity12 | Not necessarily associated with an abnormal TCD velocity24 |
| Treatment | Blood transfusion therapy to keep hemoglobin S less than 30%7 | No established treatment Focus of SIT Trial |