Naturally occurring compounds that target DNA topoisomerase II.
| Compound . | Mechanism . | Sources . |
|---|---|---|
| a CA Austin, Biochem J 282 , 883 –9. (1992 ). | ||
| b RD Snyder, Environmental & Molecular Mutagenesis 40 , 266 –76 (2002 ). | ||
|
c JA Ross, Annu Rev Nutr 22 , 19 –34 (2002 ). | ||
| d J Markovits, Cancer Res 49 , 5111 –7. (1989 ). | ||
| e A Corbett, Chem Res Toxicol 6 , 585 –597 (1993 ). | ||
| f DA Burden, Biochimica et Biophysica Acta 1400 , 139 –154 (1998 ). | ||
| g C Martin-Cordero, Zeitschrift fur Naturforschung - Section C - Biosciences 55 , 40 –3 (2000 ). | ||
| h A Constantinou, Cancer Research 50 , 2618 –24 (1990 ). | ||
| i MJ Robinson, Biochemistry 32 , 3638 –3643 (1993 ). | ||
| j KD Bromberg, Biochemistry 42 , 3393 –8 (Apr 1, 2003 ). | ||
| k RH Lindsey, Jr., Biochemistry 43 , 7563 –7574 (Jun 15, 2004 ). | ||
| l A Constantinou, Nutrition & Cancer 23 , 121 –30 (1995 ). | ||
| m CG Shin, Teratogen Carinog Mutagen 10 , 41 –52 (1990 ). | ||
| Flavonesa–c (baicalein, quercetagetin, luteolin, apigenin, acacetin) | poison | parsley, thyme, celery, sweet red pepper |
| Flavoneb (baicalein) | catalytic inhibitor | |
| Flavonolsa–c (quercetin, myricetin, fisetin) | poison | onions, kale, broccoli, apples, cherries, fennel, sorrel, berries, tea |
| Flavonolsb (fisetin, galangin, myricetin) | catalytic inhibitor | |
| Isoflavonesb–h (genistein, genistin, daidzin, 6’methoxy-pseudobaptigenin-7-O-β- glucoside) | poison (increases cleavage) | soya beans, legumes |
| Isoflavoneb (daidzein) | catalytic inhibitor | |
| Catechinsa,c ((-)-epicatechin gallate, (-)-epigallocatechin gallate) | poison | tea, apples, cocoa |
| Quercitrini | poison (increases cleavage) | |
| Quinolonee,f,i,j | poison (increases cleavage) | antimicrobial |
| 1,4-benzoquinonek | poison | benzene |
| Plant phenols (ellagic acid, flavellagic acid)l | catalytic inhibitor | blackberries, raspberries, strawberries |
| Caffeinem | catalytic inhibitor | coffee, tea, soft drinks |
| Compound . | Mechanism . | Sources . |
|---|---|---|
| a CA Austin, Biochem J 282 , 883 –9. (1992 ). | ||
| b RD Snyder, Environmental & Molecular Mutagenesis 40 , 266 –76 (2002 ). | ||
|
c JA Ross, Annu Rev Nutr 22 , 19 –34 (2002 ). | ||
| d J Markovits, Cancer Res 49 , 5111 –7. (1989 ). | ||
| e A Corbett, Chem Res Toxicol 6 , 585 –597 (1993 ). | ||
| f DA Burden, Biochimica et Biophysica Acta 1400 , 139 –154 (1998 ). | ||
| g C Martin-Cordero, Zeitschrift fur Naturforschung - Section C - Biosciences 55 , 40 –3 (2000 ). | ||
| h A Constantinou, Cancer Research 50 , 2618 –24 (1990 ). | ||
| i MJ Robinson, Biochemistry 32 , 3638 –3643 (1993 ). | ||
| j KD Bromberg, Biochemistry 42 , 3393 –8 (Apr 1, 2003 ). | ||
| k RH Lindsey, Jr., Biochemistry 43 , 7563 –7574 (Jun 15, 2004 ). | ||
| l A Constantinou, Nutrition & Cancer 23 , 121 –30 (1995 ). | ||
| m CG Shin, Teratogen Carinog Mutagen 10 , 41 –52 (1990 ). | ||
| Flavonesa–c (baicalein, quercetagetin, luteolin, apigenin, acacetin) | poison | parsley, thyme, celery, sweet red pepper |
| Flavoneb (baicalein) | catalytic inhibitor | |
| Flavonolsa–c (quercetin, myricetin, fisetin) | poison | onions, kale, broccoli, apples, cherries, fennel, sorrel, berries, tea |
| Flavonolsb (fisetin, galangin, myricetin) | catalytic inhibitor | |
| Isoflavonesb–h (genistein, genistin, daidzin, 6’methoxy-pseudobaptigenin-7-O-β- glucoside) | poison (increases cleavage) | soya beans, legumes |
| Isoflavoneb (daidzein) | catalytic inhibitor | |
| Catechinsa,c ((-)-epicatechin gallate, (-)-epigallocatechin gallate) | poison | tea, apples, cocoa |
| Quercitrini | poison (increases cleavage) | |
| Quinolonee,f,i,j | poison (increases cleavage) | antimicrobial |
| 1,4-benzoquinonek | poison | benzene |
| Plant phenols (ellagic acid, flavellagic acid)l | catalytic inhibitor | blackberries, raspberries, strawberries |
| Caffeinem | catalytic inhibitor | coffee, tea, soft drinks |