Melagatran/ximelagatran versus low molecular weight heparin (LWMH) in the prevention of venous thromboembolism (VTE).
| Surgery . | Variable . | Melagatran SC/Ximelagatran PO BID . | LMWH . | |||
|---|---|---|---|---|---|---|
| Abbreviations: THR, total hip replacement; TKR, total knee replacement | ||||||
| THR or TKR7 (N = 1900) MEHTRO II | Dose | Melagatran/Ximelagatran | Dalteparin 5000 IU QD | |||
| 1 mg/8 mg | 1.5 mg/12 mg | 2.25 mg/18 mg | 3 mg/24 mg | |||
| Overall VTE Proximal DVT Major bleeding | 37.8 8.5 0.8 | 24.1 6.2 1.2 | 23.7 3.3 3.5 | 15.1 2.1 5.5 | 28.2% 5.5 2.3 | |
| THR or TKR8 (N = 2788) METHRO III | Dose Overall VTE Proximal DVT Major bleeding | 3 mg Melagatran/Ximelagatran 24 mg 31.0% 5.7% 1.4% | Enoxaparin 40 mg QD 27.3% 6.2% 1.7% | |||
| THR or TKR9 (N = 2764) EXPRESS | Dose Overall VTE Proximal DVT Major bleeding | 2/3 mg Melagatran/Ximelagatran 24 mg 20.3% 2.3% 3.3% | Enoxaparin 40 mg QD 26.7% 6.3% 1.2% | |||
| Surgery . | Variable . | Melagatran SC/Ximelagatran PO BID . | LMWH . | |||
|---|---|---|---|---|---|---|
| Abbreviations: THR, total hip replacement; TKR, total knee replacement | ||||||
| THR or TKR7 (N = 1900) MEHTRO II | Dose | Melagatran/Ximelagatran | Dalteparin 5000 IU QD | |||
| 1 mg/8 mg | 1.5 mg/12 mg | 2.25 mg/18 mg | 3 mg/24 mg | |||
| Overall VTE Proximal DVT Major bleeding | 37.8 8.5 0.8 | 24.1 6.2 1.2 | 23.7 3.3 3.5 | 15.1 2.1 5.5 | 28.2% 5.5 2.3 | |
| THR or TKR8 (N = 2788) METHRO III | Dose Overall VTE Proximal DVT Major bleeding | 3 mg Melagatran/Ximelagatran 24 mg 31.0% 5.7% 1.4% | Enoxaparin 40 mg QD 27.3% 6.2% 1.7% | |||
| THR or TKR9 (N = 2764) EXPRESS | Dose Overall VTE Proximal DVT Major bleeding | 2/3 mg Melagatran/Ximelagatran 24 mg 20.3% 2.3% 3.3% | Enoxaparin 40 mg QD 26.7% 6.3% 1.2% | |||