Ximelagatran versus low-molecular-weight heparin (LMWH) or warfarin in the prevention of venous thromboembolism (VTE).
| Surgery . | Variable . | Ximelagatran BID . | LMWH or Warfarin . | |||
|---|---|---|---|---|---|---|
| Abbreviations: TKR, total knee replacement | ||||||
| TKR3 | Dose | 8 mg | 12 mg | 18 mg | 24 mg | Enoxaparin 30 mg BID |
| (N = 600) | Overall VTE | 27.0% | 19.8% | 28.7% | 15.8% | 22.7% |
| Proximal DVT | 6.6% | 2.0% | 5.8% | 3.2% | 3.1% | |
| Major Bleeding | 0 | 0 | 2.4% | 0 | 0.8% | |
| TKR4 | Dose | 24 mg | Enoxaparin 30 mg BID | |||
| (N = 1838) | Overall VTE | 7.9% | 4.6% | |||
| Proximal DVT | 3.6% | 1.2% | ||||
| Major Bleeding | 0.8% | 0.9% | ||||
| TKR5 | Dose | 24 mg | Warfarin INR 2.5, range 1.8–3.0 | |||
| (N = 680) | Overall VTE | 19.2% | 25.7% | |||
| Proximal DVT | 3.3% | 5.2% | ||||
| Major Bleeding | 1.7% | 0.9% | ||||
| TKR6 EXULT | Dose | 24 mg | 36 mg | Warfarin INR 2.5, range 1.8–3.0 | ||
| (N = 2301) | Overall VTE | 24.9% | 20.3% | 27.6% | ||
| Proximal DVT | 2.5% | 2.7% | 4.1% | |||
| Major Bleeding | 4.8% | 5.3% | 4.5% | |||
| Surgery . | Variable . | Ximelagatran BID . | LMWH or Warfarin . | |||
|---|---|---|---|---|---|---|
| Abbreviations: TKR, total knee replacement | ||||||
| TKR3 | Dose | 8 mg | 12 mg | 18 mg | 24 mg | Enoxaparin 30 mg BID |
| (N = 600) | Overall VTE | 27.0% | 19.8% | 28.7% | 15.8% | 22.7% |
| Proximal DVT | 6.6% | 2.0% | 5.8% | 3.2% | 3.1% | |
| Major Bleeding | 0 | 0 | 2.4% | 0 | 0.8% | |
| TKR4 | Dose | 24 mg | Enoxaparin 30 mg BID | |||
| (N = 1838) | Overall VTE | 7.9% | 4.6% | |||
| Proximal DVT | 3.6% | 1.2% | ||||
| Major Bleeding | 0.8% | 0.9% | ||||
| TKR5 | Dose | 24 mg | Warfarin INR 2.5, range 1.8–3.0 | |||
| (N = 680) | Overall VTE | 19.2% | 25.7% | |||
| Proximal DVT | 3.3% | 5.2% | ||||
| Major Bleeding | 1.7% | 0.9% | ||||
| TKR6 EXULT | Dose | 24 mg | 36 mg | Warfarin INR 2.5, range 1.8–3.0 | ||
| (N = 2301) | Overall VTE | 24.9% | 20.3% | 27.6% | ||
| Proximal DVT | 2.5% | 2.7% | 4.1% | |||
| Major Bleeding | 4.8% | 5.3% | 4.5% | |||