Main genetic abnormalities associated with pediatric acute myeloid leukemia (AML).
| Karyotype . | Genetic Lesion . | Predominant FAB type . | Frequency (%) . |
|---|---|---|---|
| *Sole chromosomal abnormality | |||
| †Sole chromosomal abnormality in non-Down syndrome | |||
| t(8;21)(q22;q22) | AML1-ETO | M2, eosinophilia | 12–15 |
| 11q23 abnormalities | MLL-several | M4, M5 | 10–15 |
| t(9;11)(p21-22;q23) | MLL-AF9 | M5 | 6–8 |
| t(15;17)(q22;q12-21) | PML-RARα | M3, M3v | 8–10 |
| Inv16(p13q22)/t(16;16)(p13;q22) | CBFβ-MYH11 | M4Eo | 6–8 |
| t(10;11)(p13;q21) | AF10-CALM | Diverse | 2 |
| t(6;9)(p23;q34) | DEK-CAN | M2, basophilia | 1 |
| t(8;16)(p11;p13)/inv(8)(p11q13) | MOZ-CBP/TIF2 | M4, M5 | 1 |
| t(1;22)(p13;q13) | RBM15-MKL1 | M7 | < 1 |
| t(3;5)(q25;q34) | NPM-MFL1 | M2 | < 1 |
| t(9;22)(q34;q11) | BCR-ABL | M1 | < 1 |
| t(11;20)(p15;q11) | NUP98-TOP1 | – | < 1 |
| Monosomy 7 or 7q deletions | Dysplasia | 2 | |
| Trisomy 8* | Diverse | 2 | |
| Trisomy 21† | M7 | 2 | |
| Complex (≥ 3 abnormalities) | Diverse | 10–15 | |
| Normal | Diverse | 20–25 | |
| Karyotype . | Genetic Lesion . | Predominant FAB type . | Frequency (%) . |
|---|---|---|---|
| *Sole chromosomal abnormality | |||
| †Sole chromosomal abnormality in non-Down syndrome | |||
| t(8;21)(q22;q22) | AML1-ETO | M2, eosinophilia | 12–15 |
| 11q23 abnormalities | MLL-several | M4, M5 | 10–15 |
| t(9;11)(p21-22;q23) | MLL-AF9 | M5 | 6–8 |
| t(15;17)(q22;q12-21) | PML-RARα | M3, M3v | 8–10 |
| Inv16(p13q22)/t(16;16)(p13;q22) | CBFβ-MYH11 | M4Eo | 6–8 |
| t(10;11)(p13;q21) | AF10-CALM | Diverse | 2 |
| t(6;9)(p23;q34) | DEK-CAN | M2, basophilia | 1 |
| t(8;16)(p11;p13)/inv(8)(p11q13) | MOZ-CBP/TIF2 | M4, M5 | 1 |
| t(1;22)(p13;q13) | RBM15-MKL1 | M7 | < 1 |
| t(3;5)(q25;q34) | NPM-MFL1 | M2 | < 1 |
| t(9;22)(q34;q11) | BCR-ABL | M1 | < 1 |
| t(11;20)(p15;q11) | NUP98-TOP1 | – | < 1 |
| Monosomy 7 or 7q deletions | Dysplasia | 2 | |
| Trisomy 8* | Diverse | 2 | |
| Trisomy 21† | M7 | 2 | |
| Complex (≥ 3 abnormalities) | Diverse | 10–15 | |
| Normal | Diverse | 20–25 | |