Post-induction minimal residual disease (MRD) patterns by age and subtype.
| Trial . | Method Sensitivity . | Age Group . | n . | % Pts MRD Neg.*; Day of CR Control . | Ref. . |
|---|---|---|---|---|---|
| # in precursor B cell (p-Bc) ALL 64%, in T-ALL 10% | |||||
| * usually defined as being below the level of sensitivity | |||||
| + median MRD levels at day 29 were significantly higher in patients 1–<2y old, 6–9y old, or ≥10y old as compared to pts 2–5y old | |||||
| Abbreviations: EORTC, European Organisation for Research and Treatment of Cancer; SJCRH, St Jude’s Cancer Research Hospital; I-BFM-SG, International Berlin-Frankfurt-Münster Study Group; NOPHO, Nordic Society for Pediatric Hematology; TCR, T cell receptor; MRD, minimal residual disease; CR, complete response; PCR, polymerase chain reaction; T ALL, T cell acute lymphoblastic leukemia | |||||
| EORTC 58881 | TCR/IgH PCR 5 × 10−5 | up to 15y | 151 | 58 #; d 35 | 81 |
| SJCRH | Flow 1 × 10−4 | 1–9y ≥ 10y | 104 55 | 80.8; d 46 67.3; d 46 | 82 |
| I-BFM-SG MRD group | TCR/IgH PCR 1 × 10−4 | 1–9y 10–18y | 142 26 | 45.1;d 33 27.0; d 33 | updated from 83 |
| NOPHO | TCR/IgH PCR 1 × 10−4 | 1–15y | 100 | 40+; d 29 | 55 |
| Trial . | Method Sensitivity . | Age Group . | n . | % Pts MRD Neg.*; Day of CR Control . | Ref. . |
|---|---|---|---|---|---|
| # in precursor B cell (p-Bc) ALL 64%, in T-ALL 10% | |||||
| * usually defined as being below the level of sensitivity | |||||
| + median MRD levels at day 29 were significantly higher in patients 1–<2y old, 6–9y old, or ≥10y old as compared to pts 2–5y old | |||||
| Abbreviations: EORTC, European Organisation for Research and Treatment of Cancer; SJCRH, St Jude’s Cancer Research Hospital; I-BFM-SG, International Berlin-Frankfurt-Münster Study Group; NOPHO, Nordic Society for Pediatric Hematology; TCR, T cell receptor; MRD, minimal residual disease; CR, complete response; PCR, polymerase chain reaction; T ALL, T cell acute lymphoblastic leukemia | |||||
| EORTC 58881 | TCR/IgH PCR 5 × 10−5 | up to 15y | 151 | 58 #; d 35 | 81 |
| SJCRH | Flow 1 × 10−4 | 1–9y ≥ 10y | 104 55 | 80.8; d 46 67.3; d 46 | 82 |
| I-BFM-SG MRD group | TCR/IgH PCR 1 × 10−4 | 1–9y 10–18y | 142 26 | 45.1;d 33 27.0; d 33 | updated from 83 |
| NOPHO | TCR/IgH PCR 1 × 10−4 | 1–15y | 100 | 40+; d 29 | 55 |