Prognostic factors in childhood acute lymphoblastic leukemia (ALL).
| Leukemia Subtype . | Favorable Prognostic Factors . | Unfavorable Prognostic Factors . |
|---|---|---|
| *This rearrangement occurs more often in B cell precursor ALL among which it is an unfavorable feature, especially in infant cases. | ||
| B cell precursor | Hyperdiploidy (> 50 chromosomes); TEL-AML1 fusion; Trisomies 4,10, and 17 | Poor early response; MLL rearrangement in infants; Philadelphia chromosome; Leukocyte count > 50 × 109/L; Age > 10 years at diagnosis |
| T cell | HOX11 overexpression; t(11;19) with MLL-ENL fusion* | Poor early response; Low dose-intensity chemotherapy |
| Leukemia Subtype . | Favorable Prognostic Factors . | Unfavorable Prognostic Factors . |
|---|---|---|
| *This rearrangement occurs more often in B cell precursor ALL among which it is an unfavorable feature, especially in infant cases. | ||
| B cell precursor | Hyperdiploidy (> 50 chromosomes); TEL-AML1 fusion; Trisomies 4,10, and 17 | Poor early response; MLL rearrangement in infants; Philadelphia chromosome; Leukocyte count > 50 × 109/L; Age > 10 years at diagnosis |
| T cell | HOX11 overexpression; t(11;19) with MLL-ENL fusion* | Poor early response; Low dose-intensity chemotherapy |