Evidence of hypercoagulable pathology in patients with thalassemia syndromes.*
| Diagnosis . | No. of Patients . | Thromboembolic Diagnosis . | % . | Comments . |
|---|---|---|---|---|
| * This table summarized data from the Eldor and Rachmilewitz review article in Blood 2002.9 Data included are from multicenter studies, retrospective autopsy reviews and observational studies. Not all studies looked for evidence of all findings, nor did all report on the presence or absence of the spleen in patients. | ||||
| Abbreviations: TM, thalassemia; TI, thalassemia intermedia; E, hemoglobin E; TIA, transient ischemic attack; MRI, magnetic resonance imaging; DVT, deep venous thromboembolism; PE, pulmonary embolism; y, year; Pulm, pulmonary; HTN, hypertension | ||||
| β-TM | 138 | Stroke | 0.02 | Not regularly transfused |
| TIA | 20 | Not regularly transfused | ||
| β-TM | 735 | Stroke | 0.02 | Not regularly transfused |
| β-TI | 41 | Asymptomatic cerebral ischemia | 37 | By MRI, Incidence correlated positively w/age and negatively w/hgb |
| β-TM | 685 | DVT or PE | 3.95 | |
| β-TI | 52 | DVT or PE | 9.61 | |
| β-TM | 1146 | DVT or PE | 1.1 | |
| β-TM | 421 | DVT or PE | 3.3 | Median age 28 y, 15% congenital or acquired risk factors |
| β-TI | 74 | DVT or PE | 16.2 | Median age 28 y, 15% congenital or acquired risk factors |
| β-TI | 83 | DVT, PE or portal vein thrombosis | 29 | 11% of total with recurrent VTE, 99% splenectomized |
| β-TM | 33 | Pulm HTN | 85 | Age range 2–24 y, suspected microthrombi |
| β-TM+/-E | 16 | Pulm HTN | 94 | Age range 5–14 y, suspected microthrombi |
| β-TM | 35 | Pulm HTN | 75 | |
| β-TM/E | 43 | Pulm arteriolar organized thrombi | 19 | Autopsy findings, 17 splenectomized |
| β-TM | 2 | Pulm arteriolar platelet microthrombi | 2 | Autopsy findings |
| Diagnosis . | No. of Patients . | Thromboembolic Diagnosis . | % . | Comments . |
|---|---|---|---|---|
| * This table summarized data from the Eldor and Rachmilewitz review article in Blood 2002.9 Data included are from multicenter studies, retrospective autopsy reviews and observational studies. Not all studies looked for evidence of all findings, nor did all report on the presence or absence of the spleen in patients. | ||||
| Abbreviations: TM, thalassemia; TI, thalassemia intermedia; E, hemoglobin E; TIA, transient ischemic attack; MRI, magnetic resonance imaging; DVT, deep venous thromboembolism; PE, pulmonary embolism; y, year; Pulm, pulmonary; HTN, hypertension | ||||
| β-TM | 138 | Stroke | 0.02 | Not regularly transfused |
| TIA | 20 | Not regularly transfused | ||
| β-TM | 735 | Stroke | 0.02 | Not regularly transfused |
| β-TI | 41 | Asymptomatic cerebral ischemia | 37 | By MRI, Incidence correlated positively w/age and negatively w/hgb |
| β-TM | 685 | DVT or PE | 3.95 | |
| β-TI | 52 | DVT or PE | 9.61 | |
| β-TM | 1146 | DVT or PE | 1.1 | |
| β-TM | 421 | DVT or PE | 3.3 | Median age 28 y, 15% congenital or acquired risk factors |
| β-TI | 74 | DVT or PE | 16.2 | Median age 28 y, 15% congenital or acquired risk factors |
| β-TI | 83 | DVT, PE or portal vein thrombosis | 29 | 11% of total with recurrent VTE, 99% splenectomized |
| β-TM | 33 | Pulm HTN | 85 | Age range 2–24 y, suspected microthrombi |
| β-TM+/-E | 16 | Pulm HTN | 94 | Age range 5–14 y, suspected microthrombi |
| β-TM | 35 | Pulm HTN | 75 | |
| β-TM/E | 43 | Pulm arteriolar organized thrombi | 19 | Autopsy findings, 17 splenectomized |
| β-TM | 2 | Pulm arteriolar platelet microthrombi | 2 | Autopsy findings |