Single versus double autologous stem cell transplantation (ASCT). Results of randomized studies.
| . | . | Preparative Regimen . | CR Rate (%) . | EFS (months) . | OS (months) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Study (Ref) . | No. of Pts . | Age . | Single . | Double . | Difference . | Single vs Double . | p value . | Single vs Double . | p value . | Single vs Double . | p value . |
| Abbreviations: CR, complete remission; EFS, event-free survival; OS, overall survival; IFM, Intergroupe Francophone du Myelome; MAG, Myelome Auto Greffe; GMMG, German Multiple Myeloma Group; Mel, melphalan; TBI, total body irradiation; BU, busulfan; Cy, cyclophosphamide; VP16, etoposide; | |||||||||||
| IFM94 (10) | 399 | < 61 | Mel140+TBI | Mel280+TBI | Mel140 | 42 vs 50 | 0.10 | 25 vs 30 | 0.03 | 48 vs 58 | 0.01 |
| MAG 95 (14) | 227 | < 56 | Mel140+ multidrug + TBI | Mel280+ VP16+TBI | < Mel140 | 39 vs 37 | NS | 31 vs 33 | NS | 49 vs 73 | 0.14 |
| Bologna (11) | 220 | < 61 | Mel200 | Mel320+ BU12 | Mel120+ BU12 | 31 vs 43 | NS | 21 vs 31 | 0.02 | 56 vs 60 | NS |
| GMMG (15) | 261 | < 66 | Mel200 | Mel400 | Mel200 | – | – | 23 vs NR | 0.03 | – | – |
| Hovon (13) | 303 | < 66 | Mel140 | Mel140+ Cy120+TBI | Cy120+TBI | 13 vs 28 | 0.002 | 20 vs 22 | 0.01 | 55 vs 50 | NS |
| . | . | Preparative Regimen . | CR Rate (%) . | EFS (months) . | OS (months) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Study (Ref) . | No. of Pts . | Age . | Single . | Double . | Difference . | Single vs Double . | p value . | Single vs Double . | p value . | Single vs Double . | p value . |
| Abbreviations: CR, complete remission; EFS, event-free survival; OS, overall survival; IFM, Intergroupe Francophone du Myelome; MAG, Myelome Auto Greffe; GMMG, German Multiple Myeloma Group; Mel, melphalan; TBI, total body irradiation; BU, busulfan; Cy, cyclophosphamide; VP16, etoposide; | |||||||||||
| IFM94 (10) | 399 | < 61 | Mel140+TBI | Mel280+TBI | Mel140 | 42 vs 50 | 0.10 | 25 vs 30 | 0.03 | 48 vs 58 | 0.01 |
| MAG 95 (14) | 227 | < 56 | Mel140+ multidrug + TBI | Mel280+ VP16+TBI | < Mel140 | 39 vs 37 | NS | 31 vs 33 | NS | 49 vs 73 | 0.14 |
| Bologna (11) | 220 | < 61 | Mel200 | Mel320+ BU12 | Mel120+ BU12 | 31 vs 43 | NS | 21 vs 31 | 0.02 | 56 vs 60 | NS |
| GMMG (15) | 261 | < 66 | Mel200 | Mel400 | Mel200 | – | – | 23 vs NR | 0.03 | – | – |
| Hovon (13) | 303 | < 66 | Mel140 | Mel140+ Cy120+TBI | Cy120+TBI | 13 vs 28 | 0.002 | 20 vs 22 | 0.01 | 55 vs 50 | NS |