Risk of recurrent venous thromboembolism (VTE) after stopping anticoagulant therapy.
| Variable . | Relative Risk . |
|---|---|
| For supporting references, see text and Kearon5 | |
| Abbreviations: DVT, deep venous thrombosis; PE, pulmonary embolism | |
| Transient risk factor | ≤ 0.5 |
| Persistent risk factor | ≥ 2 |
| Unprovoked VTE | ≥ 2 |
| Protein C, protein S and antithrombin deficiency | 1–3 |
| Heterozygous for factor V Leiden | 1–2 |
| Homozygous for factor V Leiden | 4.1 |
| Heterozygous for G20210A mutation in the prothrombin gene | 1–2 |
| Heterozygous for both factor V Leiden and G20210A prothrombin gene | 2–5 |
| Factor VIII level > 200 IU/dL | ~6 |
| Antiphospholipid antibodies | 2–4 |
| Mild hyperhomocysteinemia | 2.7 |
| D-dimer elevation after stopping therapy | ~2 |
| Family history of VTE | ~1 |
| Cancer: | ~3 |
| Metastatic vs non-metastatic | ~3 |
| Chemotherapy | ~2 |
| Discontinuation of estrogen | < 1 |
| Proximal DVT versus PE | ~1 |
| Distal DVT versus proximal DVT or PE | 0.5 |
| Residual thrombosis | 1–2 |
| Vena caval filter | ~1.8 |
| Second versus first episode of VTE | ~1.5 |
| Age at diagnosis of VTE | ≥1 |
| Male gender | ~1.5 |
| Asian | ~0.8 |
| Variable . | Relative Risk . |
|---|---|
| For supporting references, see text and Kearon5 | |
| Abbreviations: DVT, deep venous thrombosis; PE, pulmonary embolism | |
| Transient risk factor | ≤ 0.5 |
| Persistent risk factor | ≥ 2 |
| Unprovoked VTE | ≥ 2 |
| Protein C, protein S and antithrombin deficiency | 1–3 |
| Heterozygous for factor V Leiden | 1–2 |
| Homozygous for factor V Leiden | 4.1 |
| Heterozygous for G20210A mutation in the prothrombin gene | 1–2 |
| Heterozygous for both factor V Leiden and G20210A prothrombin gene | 2–5 |
| Factor VIII level > 200 IU/dL | ~6 |
| Antiphospholipid antibodies | 2–4 |
| Mild hyperhomocysteinemia | 2.7 |
| D-dimer elevation after stopping therapy | ~2 |
| Family history of VTE | ~1 |
| Cancer: | ~3 |
| Metastatic vs non-metastatic | ~3 |
| Chemotherapy | ~2 |
| Discontinuation of estrogen | < 1 |
| Proximal DVT versus PE | ~1 |
| Distal DVT versus proximal DVT or PE | 0.5 |
| Residual thrombosis | 1–2 |
| Vena caval filter | ~1.8 |
| Second versus first episode of VTE | ~1.5 |
| Age at diagnosis of VTE | ≥1 |
| Male gender | ~1.5 |
| Asian | ~0.8 |