Distinguishing features of mantle cell lymphoma (MCL) compared to three non-Hodgkin’s lymphoma (NHL) subtypes.
| Pathology . | . | Immunophenotype . |
|---|---|---|
| Follicular center cell lymphoma | FCCL | CD5−, CD23±, CD10+, CD43− |
| Small cleaved cell | Grade 1 | |
| Mixed small cleaved and large cell | Grade 2 | |
| Large cell | Grade 3 | |
| Small lymphocytic lymphoma with plasmacytoid differentiation | SLL-pl | CD5−, CD23−, CD10−, CD43± |
| Small lymphocytic lymphoma (CLL type) | SLL | CD5+, CD23+, CD43+, CD11a+, FMC7− |
| Mantle cell lymphoma | MCL | CD5+, CD23−, CD10±, CD43+, CyclinD1+, FMC7+ |
| Marginal zone lymphoma | MZL | CD5−, CD23−, CD10−, CD43± |
| Mucosa-associated lymphoid tissue | MALT | |
| Monocytoid B-cell lymphoma | MBCL | |
| Splenic | SMZL | |
| Splenic lymphoma with villous lymphocytes | SLVL | CD5−, CD11c±, FMC7+, CD22+, CD24+ |
| Hairy cell leukemia | HCL | CD5−, CD10−, CD25+, CD11c+, CD103+, B-ly-7+ |
| Pathology . | . | Immunophenotype . |
|---|---|---|
| Follicular center cell lymphoma | FCCL | CD5−, CD23±, CD10+, CD43− |
| Small cleaved cell | Grade 1 | |
| Mixed small cleaved and large cell | Grade 2 | |
| Large cell | Grade 3 | |
| Small lymphocytic lymphoma with plasmacytoid differentiation | SLL-pl | CD5−, CD23−, CD10−, CD43± |
| Small lymphocytic lymphoma (CLL type) | SLL | CD5+, CD23+, CD43+, CD11a+, FMC7− |
| Mantle cell lymphoma | MCL | CD5+, CD23−, CD10±, CD43+, CyclinD1+, FMC7+ |
| Marginal zone lymphoma | MZL | CD5−, CD23−, CD10−, CD43± |
| Mucosa-associated lymphoid tissue | MALT | |
| Monocytoid B-cell lymphoma | MBCL | |
| Splenic | SMZL | |
| Splenic lymphoma with villous lymphocytes | SLVL | CD5−, CD11c±, FMC7+, CD22+, CD24+ |
| Hairy cell leukemia | HCL | CD5−, CD10−, CD25+, CD11c+, CD103+, B-ly-7+ |