Vegf molecules injected into vegfaa mutant animals and rescue percentages
| Ligand or amino acid . | Rescue % . |
|---|---|
| Vegf | |
| Vegfaa-121 | 57.7 ± 5.2 |
| Vegfaa-165 | 76.8 ± 4.1 |
| Vegfbb | 84.4 ± 3.5 |
| Vegfd | 89.3 ± 4.9 |
| Plgfb | 97.9 ± 1.2 |
| Vegfab-171 | 3 ± 1.3 |
| Vegfab-210 | 0 |
| Vegfba | 0 |
| Vegfc | 1 ± 1 |
| ∆C∆NVEGFC | 0 |
| Vegfab-171* | 81 ± 5 |
| Vegfaa-121 Vegfr2 determinants | |
| F17A | 0 |
| M18A | 0 |
| I43A | 0 |
| T46A | 0 |
| Y47A | 0 |
| E64A | 0 |
| V83A | 0 |
| K84A | 0 |
| Vegfaa-165 Vegfr1 determinant | |
| D63A/E64A/E67A | 52.5 |
| Vegfaa-165 Vegfr2 determinants | |
| F17A | 88.9 ± 7.8 |
| K84A | 89 ± 5.4 |
| Y47A/K84A | 0 |
| E64A/K84A | 0 |
| Vegfaa-165 Nrp1 determinants | |
| E153A | 77.5 ± 3.7 |
| R165A | 81.1 ± 3.9 |
| Pgfb Nrp1 determinants | |
| R158A | 89.8 ± 5.9 |
| Pgfb Vegfr2 determinants | |
| F17A | 93.2 ± 6.1 |
| E64A | 91 ± 4.5 |
| K84A | 95 ± 3.1 |
| F17A/K84A | 94.7 ± 2.1 |
| E64A/K84A | 89.9 ± 7.5 |
| F17A/E64A/K84A | 88 ± 5.9 |
| Pgfb Vegfr1 determinant | |
| D63A/E64A/E67A | 43 |
| Ligand or amino acid . | Rescue % . |
|---|---|
| Vegf | |
| Vegfaa-121 | 57.7 ± 5.2 |
| Vegfaa-165 | 76.8 ± 4.1 |
| Vegfbb | 84.4 ± 3.5 |
| Vegfd | 89.3 ± 4.9 |
| Plgfb | 97.9 ± 1.2 |
| Vegfab-171 | 3 ± 1.3 |
| Vegfab-210 | 0 |
| Vegfba | 0 |
| Vegfc | 1 ± 1 |
| ∆C∆NVEGFC | 0 |
| Vegfab-171* | 81 ± 5 |
| Vegfaa-121 Vegfr2 determinants | |
| F17A | 0 |
| M18A | 0 |
| I43A | 0 |
| T46A | 0 |
| Y47A | 0 |
| E64A | 0 |
| V83A | 0 |
| K84A | 0 |
| Vegfaa-165 Vegfr1 determinant | |
| D63A/E64A/E67A | 52.5 |
| Vegfaa-165 Vegfr2 determinants | |
| F17A | 88.9 ± 7.8 |
| K84A | 89 ± 5.4 |
| Y47A/K84A | 0 |
| E64A/K84A | 0 |
| Vegfaa-165 Nrp1 determinants | |
| E153A | 77.5 ± 3.7 |
| R165A | 81.1 ± 3.9 |
| Pgfb Nrp1 determinants | |
| R158A | 89.8 ± 5.9 |
| Pgfb Vegfr2 determinants | |
| F17A | 93.2 ± 6.1 |
| E64A | 91 ± 4.5 |
| K84A | 95 ± 3.1 |
| F17A/K84A | 94.7 ± 2.1 |
| E64A/K84A | 89.9 ± 7.5 |
| F17A/E64A/K84A | 88 ± 5.9 |
| Pgfb Vegfr1 determinant | |
| D63A/E64A/E67A | 43 |
Values represent the average percentage of rescue from 3 to 10 biological replicates ± standard error. Vegfab-171* refers to a chimera where the Vegfab signal peptide was replaced with that of Vegfaa.