Table 1. Clinical characteristics of... | American Society of Hematology

Table 1.

Clinical characteristics of patients who have MDS with TP53 mutations

Characteristic	TP53-mutant MDS (n = 261)				TP53-wildtype MDS (n = 677)				P
Characteristic	n	%	Median	Range	n	%	Median	Range	P
Median age, y			68	18-90			67	22-93	.770
Male sex	157	61			444	67			.101
Hemoglobin, g/dL			9.2	8.9-9.4			12	7.9-16.1	.408
WBC, × 10⁹/L			3.7	3.4-4.1			4.1	3.8-4.3	.211
Platelets, × 10⁹/L			84	73-95			130	122-139	<.001
ANC, × 10⁹/L			1.9	1.6-2.1			2.2	2.0-2.4	.023
Median BM blast %			6	0-18			3	0-19	<.001
WHO MDS diagnosis									<.001
Single lineage dysplasia	16	6			41	6
Multilineage dysplasia	52	20			212	31
Ring sideroblasts	22	8			101	15
Excess blasts	150	58			266	39
Unrecognized	15	6			42	6
del(5q)	5	2			15	2
Not available	0	0			1	0
IPSS-R risk category									<.001
Very low	8	3			88	13
Low	17	7			217	32
Intermediate	18	7			88	24
High	48	18			124	19
Very high	170	65			78	12
Not available	0	0			8
IPSS-R cytogenetic group									<.001
Very good	3	1			18	3
Good	27	10			423	63
Intermediate	6	2			113	17
Poor	7	3			55	8
Very poor	218	84			60	9
Complex karyotype	217	83			60	9			<.001
Therapy related	138	53			91	13			<.001
Prior chemotherapy	131	50			80	12
Prior radiation	70	27			58	9

Characteristic	TP53-mutant MDS (n = 261)				TP53-wildtype MDS (n = 677)				P
Characteristic	n	%	Median	Range	n	%	Median	Range	P
Median age, y			68	18-90			67	22-93	.770
Male sex	157	61			444	67			.101
Hemoglobin, g/dL			9.2	8.9-9.4			12	7.9-16.1	.408
WBC, × 10⁹/L			3.7	3.4-4.1			4.1	3.8-4.3	.211
Platelets, × 10⁹/L			84	73-95			130	122-139	<.001
ANC, × 10⁹/L			1.9	1.6-2.1			2.2	2.0-2.4	.023
Median BM blast %			6	0-18			3	0-19	<.001
WHO MDS diagnosis									<.001
Single lineage dysplasia	16	6			41	6
Multilineage dysplasia	52	20			212	31
Ring sideroblasts	22	8			101	15
Excess blasts	150	58			266	39
Unrecognized	15	6			42	6
del(5q)	5	2			15	2
Not available	0	0			1	0
IPSS-R risk category									<.001
Very low	8	3			88	13
Low	17	7			217	32
Intermediate	18	7			88	24
High	48	18			124	19
Very high	170	65			78	12
Not available	0	0			8
IPSS-R cytogenetic group									<.001
Very good	3	1			18	3
Good	27	10			423	63
Intermediate	6	2			113	17
Poor	7	3			55	8
Very poor	218	84			60	9
Complex karyotype	217	83			60	9			<.001
Therapy related	138	53			91	13			<.001
Prior chemotherapy	131	50			80	12
Prior radiation	70	27			58	9

ANC, absolute neutrophil count; WBC, white blood cell count.