The overall ZIP δ synergy score was based on the entire range of doses tested, and the most synergistic area score was based on the specific concentrations that had the highest synergy for each AML and DLBCL sample tested. Red shading indicates synergistic ZIP scores >0, green shading indicates antagonistic ZIP scores <0. AML samples that responded to venetoclax in the clinic are indicated by an orange font. AML samples that were primary induction refractory to venetoclax in the clinic are indicated by a lavender font.