Table 1. Summary of peripheral blood... | American Society of Hematology

Table 1.

Summary of peripheral blood cellular kinetic parameters by flow cytometry for tisagenlecleucel by response at month 3

Parameter	CR/PR	SD/PD/unknown
AUC_0-28d, %CD3⁺CAR⁺cells*× d	n = 35†	n = 44†
Geometric mean (% CV)	36.9 (214.7)	42.0 (299.3)
C_max, %CD3⁺CAR⁺cells*	n = 34	n = 50
Geometric mean (% CV)	4.81 (169.7)	4.18 (232.9)
Range	(0.600-40.9)	(0.300-61.5)
t_max, d	n = 34	n = 50
Median (range)	6.35 (2.91-271)	7.64 (2.82-25.9)
C_last,%CD3⁺CAR⁺cells*	n = 35	n = 50
Geometric mean (% CV)	0.289 (165.2)	0.539 (313.2)
t_last, d	n = 35	n = 50
Median (range)	280 (21-554)	28.1 (9.01-400)

Parameter	CR/PR	SD/PD/unknown
AUC_0-28d, %CD3⁺CAR⁺cells*× d	n = 35†	n = 44†
Geometric mean (% CV)	36.9 (214.7)	42.0 (299.3)
C_max, %CD3⁺CAR⁺cells*	n = 34	n = 50
Geometric mean (% CV)	4.81 (169.7)	4.18 (232.9)
Range	(0.600-40.9)	(0.300-61.5)
t_max, d	n = 34	n = 50
Median (range)	6.35 (2.91-271)	7.64 (2.82-25.9)
C_last,%CD3⁺CAR⁺cells*	n = 35	n = 50
Geometric mean (% CV)	0.289 (165.2)	0.539 (313.2)
t_last, d	n = 35	n = 50
Median (range)	280 (21-554)	28.1 (9.01-400)

CV, coefficient of variation; PR, partial response; SD, stable disease.

Percentage of CAR⁺ cells among CD3⁺ T cells.

Patients who had ≥1 sample with evaluable cellular kinetics data were included.