Summary of PK parameters of patients on the Q3W dosing regimen (≥90 μg/kg)
| Cohort, µg/kg . | Arithmetic mean (CV%); n . | |||||
|---|---|---|---|---|---|---|
| Cycle 1 . | Cycle 2 . | |||||
| CL, L/d . | Vdβ, L . | Thalf, d . | CLSS, L/d . | Vdβ, L . | Thalf, d . | |
| Conjugated Ab | ||||||
| 90 | 80.8 (131); 3 | 10.5 (121); 3 | 0.355 (141); 3 | 9.63 (130); 2 | 5.61 (-); 1 | 4.96 (-); 1 |
| 120 | 84.3 (121); 2 | 6.89 (45.5); 2 | 0.156 (105); 2 | 31.1 (119); 4 | 8.33 (65.1); 3 | 7.55 (136); 3 |
| 150 | 27.4 (45.2); 5 | 34.2 (104); 5 | 0.713 (83.6); 5 | 1.57 (46.2); 4 | 9.45 (55.7); 4 | 3.99 (18.1); 4 |
| Total Ab | ||||||
| 90 | 3.98 (—); 1 | 4.50 (—); 1 | 0.784 (—); 1 | 0.831 (—); 1 | 6.71 (—); 1 | 5.59 (—); 1 |
| 120 | — | — | — | 10.3 (162); 4 | 11.4 (0.891); 2 | 14.5 (113); 2 |
| 150 | 18.9 (115); 2 | 2.68 (11.5); 2 | 0.275 (111); 2 | 1.37 (47.9); 4 | 9.14 (65.2); 3 | 4.67 (35.9); 3 |
| SG3199 | ||||||
| 90 | — | — | — | — | — | — |
| 120 | — | — | — | 838 (—); 1 | 614 (—); 1 | 0.508 (—); 1 |
| 150 | — | — | — | — | — | — |
| Cohort, µg/kg . | Arithmetic mean (CV%); n . | |||||
|---|---|---|---|---|---|---|
| Cycle 1 . | Cycle 2 . | |||||
| CL, L/d . | Vdβ, L . | Thalf, d . | CLSS, L/d . | Vdβ, L . | Thalf, d . | |
| Conjugated Ab | ||||||
| 90 | 80.8 (131); 3 | 10.5 (121); 3 | 0.355 (141); 3 | 9.63 (130); 2 | 5.61 (-); 1 | 4.96 (-); 1 |
| 120 | 84.3 (121); 2 | 6.89 (45.5); 2 | 0.156 (105); 2 | 31.1 (119); 4 | 8.33 (65.1); 3 | 7.55 (136); 3 |
| 150 | 27.4 (45.2); 5 | 34.2 (104); 5 | 0.713 (83.6); 5 | 1.57 (46.2); 4 | 9.45 (55.7); 4 | 3.99 (18.1); 4 |
| Total Ab | ||||||
| 90 | 3.98 (—); 1 | 4.50 (—); 1 | 0.784 (—); 1 | 0.831 (—); 1 | 6.71 (—); 1 | 5.59 (—); 1 |
| 120 | — | — | — | 10.3 (162); 4 | 11.4 (0.891); 2 | 14.5 (113); 2 |
| 150 | 18.9 (115); 2 | 2.68 (11.5); 2 | 0.275 (111); 2 | 1.37 (47.9); 4 | 9.14 (65.2); 3 | 4.67 (35.9); 3 |
| SG3199 | ||||||
| 90 | — | — | — | — | — | — |
| 120 | — | — | — | 838 (—); 1 | 614 (—); 1 | 0.508 (—); 1 |
| 150 | — | — | — | — | — | — |
CL, clearance; CLss, clearance at steady state; Thalf, apparent terminal half-life; Vdβ, volume of distribution at terminal phase.