Treatment-emergent AEs of any grade, irrespective of causality, reported in ≥20% of patients
| Patients with AE, n (%) . | Ivosidenib 500 mg, N = 34 . | |
|---|---|---|
| Any grade . | Grade ≥3 . | |
| Any AE | 34 (100) | 27 (79) |
| Diarrhea | 18 (53) | 2 (6) |
| Fatigue | 16 (47) | 4 (12) |
| Nausea | 13 (38) | 2 (6) |
| Decreased appetite | 12 (35) | 1 (3) |
| Thrombocytopenia | 9 (26) | 5 (15) |
| Anemia | 9 (26) | 4 (12) |
| Leukocytosis | 9 (26) | 1 (3) |
| Peripheral edema | 9 (26) | 0 |
| Dyspnea | 8 (24) | 1 (3) |
| Dizziness | 8 (24) | 0 |
| Hypomagnesemia | 8 (24) | 0 |
| Abdominal pain | 7 (21) | 1 (3) |
| Arthralgia | 7 (21) | 1 (3) |
| Constipation | 7 (21) | 1 (3) |
| Epistaxis | 7 (21) | 0 |
| Hypokalemia | 7 (21) | 1 (3) |
| Insomnia | 7 (21) | 0 |
| Patients with AE, n (%) . | Ivosidenib 500 mg, N = 34 . | |
|---|---|---|
| Any grade . | Grade ≥3 . | |
| Any AE | 34 (100) | 27 (79) |
| Diarrhea | 18 (53) | 2 (6) |
| Fatigue | 16 (47) | 4 (12) |
| Nausea | 13 (38) | 2 (6) |
| Decreased appetite | 12 (35) | 1 (3) |
| Thrombocytopenia | 9 (26) | 5 (15) |
| Anemia | 9 (26) | 4 (12) |
| Leukocytosis | 9 (26) | 1 (3) |
| Peripheral edema | 9 (26) | 0 |
| Dyspnea | 8 (24) | 1 (3) |
| Dizziness | 8 (24) | 0 |
| Hypomagnesemia | 8 (24) | 0 |
| Abdominal pain | 7 (21) | 1 (3) |
| Arthralgia | 7 (21) | 1 (3) |
| Constipation | 7 (21) | 1 (3) |
| Epistaxis | 7 (21) | 0 |
| Hypokalemia | 7 (21) | 1 (3) |
| Insomnia | 7 (21) | 0 |