Clinical features of subjects with spontaneous CLL regression
| . | Diagnosis . | Sex . | ALC, ×109/L . | Medical history and comorbidities . | Second malignancy . | Non-CLL-related drug history . | |||
|---|---|---|---|---|---|---|---|---|---|
| Year . | Age, y . | Peak . | Current . | Site . | Diagnosis . | ||||
| Complete spontaneous regression | |||||||||
| CLL01 | 2005 | 58 | M | 9.0 | 3.2 | Osteoarthritis, hypertension, hypercholesterolemia | Prostate | 2014 | Atorvastatin, amlodipine (discontinued) |
| CLL02 | 2001 | 52 | M | 29.5 | 3.3 | Hypertension, diabetes mellitus | — | — | Metformin, ramipril, bendroflumethiazide, doxazosin, verapamil |
| CLL03 | 1996 | 66 | M | 32.7 | 1.5 | Ischemic heart disease, peripheral vascular disease, diabetes mellitus, bronchiectasis (since 2010), hypertension | — | — | Alfuzosin, aspirin, bendroflumethiazide, doxazosin, felodipine, lisinopril, simvastatin |
| CLL04 | 1994 | 58 | M | 10.5 | 1.7 | Hypertension, benign prostatic hypertrophy, previous neurofibroma, osteoarthritis | — | — | Finasteride, amlodipine, ibersartan |
| CLL05 | 2000 | 56 | M | 25.7 | 2.6 | Previous rectal polyp (nonmalignant), diabetes mellitus | — | — | Metformin |
| CLL06 | 1997 | 61 | M | 27.4 | 3.5 | Diabetes mellitus, hypertension | — | — | Metformin, furosemide |
| CLL07 | 2002 | 83 | M | 23.2 | 3.6 | Hypothyroidism, diabetes mellitus, hypertension, benign prostatic hypertrophy | Skin (SCC) | 2010 | Aspirin, linagliptin, tamsulosin, levothyroxine |
| CLL08 | 2002 | 72 | F | 6.7 | 2.4 | Atrial fibrillation, diverticulosis, hypertension, hyperthyroidism, cholecystitis (in 2014) | — | — | Bisoprolol |
| CLL09 | 1990 | 46 | M | 20.2 | 3.1 | Hypertension, hypercholesterolemia | — | — | Ramipril, simvastatin |
| CLL10 | 2008 | 70 | M | 13.8 | 3.2 | Hypertension, abdominal aortic aneurysm, previous TIA, hypercholesterolemia | — | — | Simvastatin, aspirin, lansoprazole, indapamide |
| CLL11 | 2007 | 75 | M | 14.5 | 1.2 | Atrial fibrillation, gout | Skin (SCC) | 2013 | Warfarin, bisoprolol, lansoprazole, febuxostat, donepezil |
| Partial spontaneous regression | |||||||||
| CLL12 | 2000 | 66 | M | 40.6 | 5.6 | Previous iron deficiency anemia | Skin (BCC) | 2010 | Omeprazole, temazepam, aspirin |
| CLL13 | 2013 | 73 | M | 161.0 | 11.3 | Abdominal aortic aneurysm, COPD | — | — | Tiotropium and salbutamol inhalers |
| CLL14 | 2002 | 73 | F | 44.5 | 8.5 | Ischemic heart disease, osteoarthritis, hypertension, hypercholesterolemia | — | — | Aspirin, ramipril, furosemide, ropinirole, levetiracetam |
| CLL15 | 2004 | 61 | M | 25.9 | 5.5 | Diabetes mellitus, hypertension, hypercholesterolemia | Simvastatin, doxazosin | ||
| CLL16 | 2007 | 36 | F | 19.6 | 7.0 | Eczema, mild depression | — | — | Nil |
| CLL17 | 2009 | 81 | M | 42.4 | 16.9 | Lewy body dementia, previous ischemic heart disease, depression | — | — | Bumetanide, citalopram, donepezil |
| Spontaneous regression occurring prior to a second malignancy | |||||||||
| CLL18 | 2008 | 60 | M | 50.2 | 3.0 | Diabetes mellitus, hypertension | Prostate | 2010 | Aspirin, enalapril, metformin, pioglitazone, simvastatin, tamsulosin |
| CLL19 | 1987 | 55 | M | 78.0 | 7.7 | Diverticulosis, COPD, gout | Lung | 2010 | Carbocisteine, tamsulosin, tiotropium/fluticasone/ salmeterol inhalers |
| Relapsed spontaneous regression | |||||||||
| CLL20 | 1993 | 38 | M | 52.4 | 20.0 | Hypercholesterolemia, asthma, previous hip replacement | — | — | Simvastatin, salbutamol/formoterol inhalers |
| . | Diagnosis . | Sex . | ALC, ×109/L . | Medical history and comorbidities . | Second malignancy . | Non-CLL-related drug history . | |||
|---|---|---|---|---|---|---|---|---|---|
| Year . | Age, y . | Peak . | Current . | Site . | Diagnosis . | ||||
| Complete spontaneous regression | |||||||||
| CLL01 | 2005 | 58 | M | 9.0 | 3.2 | Osteoarthritis, hypertension, hypercholesterolemia | Prostate | 2014 | Atorvastatin, amlodipine (discontinued) |
| CLL02 | 2001 | 52 | M | 29.5 | 3.3 | Hypertension, diabetes mellitus | — | — | Metformin, ramipril, bendroflumethiazide, doxazosin, verapamil |
| CLL03 | 1996 | 66 | M | 32.7 | 1.5 | Ischemic heart disease, peripheral vascular disease, diabetes mellitus, bronchiectasis (since 2010), hypertension | — | — | Alfuzosin, aspirin, bendroflumethiazide, doxazosin, felodipine, lisinopril, simvastatin |
| CLL04 | 1994 | 58 | M | 10.5 | 1.7 | Hypertension, benign prostatic hypertrophy, previous neurofibroma, osteoarthritis | — | — | Finasteride, amlodipine, ibersartan |
| CLL05 | 2000 | 56 | M | 25.7 | 2.6 | Previous rectal polyp (nonmalignant), diabetes mellitus | — | — | Metformin |
| CLL06 | 1997 | 61 | M | 27.4 | 3.5 | Diabetes mellitus, hypertension | — | — | Metformin, furosemide |
| CLL07 | 2002 | 83 | M | 23.2 | 3.6 | Hypothyroidism, diabetes mellitus, hypertension, benign prostatic hypertrophy | Skin (SCC) | 2010 | Aspirin, linagliptin, tamsulosin, levothyroxine |
| CLL08 | 2002 | 72 | F | 6.7 | 2.4 | Atrial fibrillation, diverticulosis, hypertension, hyperthyroidism, cholecystitis (in 2014) | — | — | Bisoprolol |
| CLL09 | 1990 | 46 | M | 20.2 | 3.1 | Hypertension, hypercholesterolemia | — | — | Ramipril, simvastatin |
| CLL10 | 2008 | 70 | M | 13.8 | 3.2 | Hypertension, abdominal aortic aneurysm, previous TIA, hypercholesterolemia | — | — | Simvastatin, aspirin, lansoprazole, indapamide |
| CLL11 | 2007 | 75 | M | 14.5 | 1.2 | Atrial fibrillation, gout | Skin (SCC) | 2013 | Warfarin, bisoprolol, lansoprazole, febuxostat, donepezil |
| Partial spontaneous regression | |||||||||
| CLL12 | 2000 | 66 | M | 40.6 | 5.6 | Previous iron deficiency anemia | Skin (BCC) | 2010 | Omeprazole, temazepam, aspirin |
| CLL13 | 2013 | 73 | M | 161.0 | 11.3 | Abdominal aortic aneurysm, COPD | — | — | Tiotropium and salbutamol inhalers |
| CLL14 | 2002 | 73 | F | 44.5 | 8.5 | Ischemic heart disease, osteoarthritis, hypertension, hypercholesterolemia | — | — | Aspirin, ramipril, furosemide, ropinirole, levetiracetam |
| CLL15 | 2004 | 61 | M | 25.9 | 5.5 | Diabetes mellitus, hypertension, hypercholesterolemia | Simvastatin, doxazosin | ||
| CLL16 | 2007 | 36 | F | 19.6 | 7.0 | Eczema, mild depression | — | — | Nil |
| CLL17 | 2009 | 81 | M | 42.4 | 16.9 | Lewy body dementia, previous ischemic heart disease, depression | — | — | Bumetanide, citalopram, donepezil |
| Spontaneous regression occurring prior to a second malignancy | |||||||||
| CLL18 | 2008 | 60 | M | 50.2 | 3.0 | Diabetes mellitus, hypertension | Prostate | 2010 | Aspirin, enalapril, metformin, pioglitazone, simvastatin, tamsulosin |
| CLL19 | 1987 | 55 | M | 78.0 | 7.7 | Diverticulosis, COPD, gout | Lung | 2010 | Carbocisteine, tamsulosin, tiotropium/fluticasone/ salmeterol inhalers |
| Relapsed spontaneous regression | |||||||||
| CLL20 | 1993 | 38 | M | 52.4 | 20.0 | Hypercholesterolemia, asthma, previous hip replacement | — | — | Simvastatin, salbutamol/formoterol inhalers |
—, no known second malignancy; ALC, absolute lymphocyte count; BCC, basal cell carcinoma; COPD, chronic obstructive pulmonary disease; F, female; M, male; SCC, squamous cell carcinoma; TIA, transient ischemic attack.