Table 2.

Multivariate analysis for OS, NRM, and CIR

Variablesn (%)OSNRMCIR
Multivariate analysisMultivariate analysisMultivariate analysis
HR95% CIPHR95% CIPHR95% CIP
Clinical factors           
 Age (<51 y) 150 (48.4)       1.55 0.80-3.29 .194 
 Male sex 181 (58.4)       1.12 0.60-2.12 .729 
 HCT-CI, <3 114 (36.8) 0.41 0.26-0.63 .002 0.58 0.32-0.88 .008    
 R-DRI  2.35 1.15-5.48 <.001 1.24 1.02-2.58 .046 1.38 1.04-1.78 <.001 
  Low risk 82 (26.4) 0.62 0.34-1.26 .140 0.44 0.21-1.09 .082 0.75 0.58-0.97 .033 
  Intermediate risk 92 (29.7) 1.00 Ref.  1 Ref.  1.00 Ref.  
  High risk 70 (22.6) 2.27 1.22-3.59 .002 1.34 0.59-3.02 .550 1.84 1.04-3.34 .038 
  Very high risk 66 (21.3) 6.15 1.83-6.03 <.001 1.98 0.98-4.35 .061 4.73 2.52-7.15 <.001 
 Conditioning regimens (RIC) 199 (64.2)    0.87 0.4-1.08 .060 0.80 0.39-1.57 .489 
 Donor relation (related donor) 84 (27.1)       1.24 0.88-1.20 .192 
 HLA compatibility (HLA match) 173 (55.8) 0.89 0.49-1.59 .688    0.86 0.51-1.24 .317 
 Stem cell sources           
  CB 136 (43.9) 0.66 0.30-1.41 .281    0.60 0.36-1.02 .060 
  BM 119 (38.4) 1.00 Ref.     1.00 Ref.  
  PBSC 55 (17.7) 0.79 0.45-1.41 .432    1.21 0.66-2.15 .482 
 Sex mismatch (female to male) 75 (24.2)    2.74 0.94-7.62 .059 0.81 0.52-1.15 .162 
 Diagnosis to transplant (<180 d) 146 (47.1)       0.69 0.63-0.99 .049 
 Grade 2-4 acute GVHD by day 100 130 (42.0) 0.93 0.61-1.42 .729 1.58 1.01-2.48 .046 0.65 0.41-1.00 .051 
Immunologic factors           
 CD20+ B cell (high) 135 (43.5) 0.39 0.20-0.74 <.001 0.34 0.11-0.68 .007    
 CD8+CD11b− T cell (high) 194 (62.6) 0.40 0.24-0.69 <.001 0.35 0.22-0.49 .004    
 CD3−CD56+ NK cell (high) 210 (67.7) 0.65 0.39-1.08 .090 0.51 0.47-1.84 .290    
 CD16+CD57− NK cell (high) 185 (59.7) 0.31 0.18-0.82 <.001 0.92 0.43-1.15 .081 0.38 0.24-0.80 .009 
 CD16+CD57+ NK cell (high) 162 (52.3) 0.75 0.43-1.30 .306 0.89 0.41-2.50 .870 0.51 0.26-0.94 .034 
Variablesn (%)OSNRMCIR
Multivariate analysisMultivariate analysisMultivariate analysis
HR95% CIPHR95% CIPHR95% CIP
Clinical factors           
 Age (<51 y) 150 (48.4)       1.55 0.80-3.29 .194 
 Male sex 181 (58.4)       1.12 0.60-2.12 .729 
 HCT-CI, <3 114 (36.8) 0.41 0.26-0.63 .002 0.58 0.32-0.88 .008    
 R-DRI  2.35 1.15-5.48 <.001 1.24 1.02-2.58 .046 1.38 1.04-1.78 <.001 
  Low risk 82 (26.4) 0.62 0.34-1.26 .140 0.44 0.21-1.09 .082 0.75 0.58-0.97 .033 
  Intermediate risk 92 (29.7) 1.00 Ref.  1 Ref.  1.00 Ref.  
  High risk 70 (22.6) 2.27 1.22-3.59 .002 1.34 0.59-3.02 .550 1.84 1.04-3.34 .038 
  Very high risk 66 (21.3) 6.15 1.83-6.03 <.001 1.98 0.98-4.35 .061 4.73 2.52-7.15 <.001 
 Conditioning regimens (RIC) 199 (64.2)    0.87 0.4-1.08 .060 0.80 0.39-1.57 .489 
 Donor relation (related donor) 84 (27.1)       1.24 0.88-1.20 .192 
 HLA compatibility (HLA match) 173 (55.8) 0.89 0.49-1.59 .688    0.86 0.51-1.24 .317 
 Stem cell sources           
  CB 136 (43.9) 0.66 0.30-1.41 .281    0.60 0.36-1.02 .060 
  BM 119 (38.4) 1.00 Ref.     1.00 Ref.  
  PBSC 55 (17.7) 0.79 0.45-1.41 .432    1.21 0.66-2.15 .482 
 Sex mismatch (female to male) 75 (24.2)    2.74 0.94-7.62 .059 0.81 0.52-1.15 .162 
 Diagnosis to transplant (<180 d) 146 (47.1)       0.69 0.63-0.99 .049 
 Grade 2-4 acute GVHD by day 100 130 (42.0) 0.93 0.61-1.42 .729 1.58 1.01-2.48 .046 0.65 0.41-1.00 .051 
Immunologic factors           
 CD20+ B cell (high) 135 (43.5) 0.39 0.20-0.74 <.001 0.34 0.11-0.68 .007    
 CD8+CD11b− T cell (high) 194 (62.6) 0.40 0.24-0.69 <.001 0.35 0.22-0.49 .004    
 CD3−CD56+ NK cell (high) 210 (67.7) 0.65 0.39-1.08 .090 0.51 0.47-1.84 .290    
 CD16+CD57− NK cell (high) 185 (59.7) 0.31 0.18-0.82 <.001 0.92 0.43-1.15 .081 0.38 0.24-0.80 .009 
 CD16+CD57+ NK cell (high) 162 (52.3) 0.75 0.43-1.30 .306 0.89 0.41-2.50 .870 0.51 0.26-0.94 .034 
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