Patient and disease characteristics as well as incidence of 2017 ELN high-risk molecular markers by the 4 NPM1/FLT3-ITD genotypes
| . | NPM1mut/FLT3-ITDlow . | NPM1mut/FLT3-ITDhigh . | NPM1wt/FLT3-ITDlow . | NPM1wt/FLT3-ITDhigh . | P . |
|---|---|---|---|---|---|
| Patients, n (%) | 85 (19.9) | 159 (37.2) | 74 (17.3) | 109 (25.5) | |
| Age, median, y | 50.6 | 48.1 | 47.2 | 45.7 | .05 |
| Female, % | 64.7 | 66.0 | 47.3 | 48.6 | .0065 |
| WBCs, median (range), ×109/L | 23.6 (1.4-253.2) | 45.3 (1.4-329.8) | 23.6 (0.6-207.4) | 44.6 (0.8-236.0) | <.0001 |
| Median BM blasts, % | 72 | 80 | 72 | 77 | .0019 |
| Incidence of 2017 ELN high-risk mutations, n (%) | |||||
| RUNX1 | 1/73 (1.4) | 1/140 (0.7) | 16/53 (30.2) | 24/92 (26.1) | .0005 |
| ASXL1 | 4/73 (5.5) | 9/140 (6.4) | 6/53 (11.3) | 12/92 (13.0) | .23 |
| TP53 | 0/73 (0) | 1/140 (0.7) | 1/53 (1.9) | 0/92 (0) | .50 |
| Karyotype, n (%) | |||||
| Normal | 52 (89.7) | 101 (90.2) | 32 (52.5) | 54 (58.1) | .0005 |
| Abnormal | 6 (10.3) | 11 (9.8) | 29 (47.5) | 39 (41.9) | |
| Missing | 27 | 47 | 13 | 16 |
| . | NPM1mut/FLT3-ITDlow . | NPM1mut/FLT3-ITDhigh . | NPM1wt/FLT3-ITDlow . | NPM1wt/FLT3-ITDhigh . | P . |
|---|---|---|---|---|---|
| Patients, n (%) | 85 (19.9) | 159 (37.2) | 74 (17.3) | 109 (25.5) | |
| Age, median, y | 50.6 | 48.1 | 47.2 | 45.7 | .05 |
| Female, % | 64.7 | 66.0 | 47.3 | 48.6 | .0065 |
| WBCs, median (range), ×109/L | 23.6 (1.4-253.2) | 45.3 (1.4-329.8) | 23.6 (0.6-207.4) | 44.6 (0.8-236.0) | <.0001 |
| Median BM blasts, % | 72 | 80 | 72 | 77 | .0019 |
| Incidence of 2017 ELN high-risk mutations, n (%) | |||||
| RUNX1 | 1/73 (1.4) | 1/140 (0.7) | 16/53 (30.2) | 24/92 (26.1) | .0005 |
| ASXL1 | 4/73 (5.5) | 9/140 (6.4) | 6/53 (11.3) | 12/92 (13.0) | .23 |
| TP53 | 0/73 (0) | 1/140 (0.7) | 1/53 (1.9) | 0/92 (0) | .50 |
| Karyotype, n (%) | |||||
| Normal | 52 (89.7) | 101 (90.2) | 32 (52.5) | 54 (58.1) | .0005 |
| Abnormal | 6 (10.3) | 11 (9.8) | 29 (47.5) | 39 (41.9) | |
| Missing | 27 | 47 | 13 | 16 |
The Fisher’s exact test was used for categorical variables, and the Kruskal-Wallis test was used for continuous variables.