Table 1.

Full list of records selected for systematic review

Clinical trialAuthorYearTitleJournal
RESPONSE Verstovsek et al24  2014 Results of a prospective, randomized, open-label phase 3 study of ruxolitinib (RUX) in polycythemia vera (PV) patients resistant to or intolerant of hydroxyurea (HU) the RESPONSE trial. Journal of Clinical Oncology 
 Vannucchi et al25  2014 Ruxolitinib proves superior to best available therapy in a prospective, randomized, phase 3 study (RESPONSE) in patients with polycythemia vera resistant to or intolerant of hydroxyurea. Haematologica 
 Vannucchi et al 2015 Ruxolitinib versus standard therapy for the treatment of polycythemia vera. The New England Journal of Medicine 
 Verstovsek et al26  2015 Safety of ruxolitinib in patients with polycythemia vera Results from the clinical trial program. Haematologica 
 Verstovsek et al 2016 Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial. Haematologica 
 Kiladjian et al27  2017 Results from the 208-week (4-year) follow-up of RESPONSE trial, a phase 3 study comparing ruxolitinib (Rux) with best available therapy (BAT) for the treatment of polycythemia vera (PV). Blood 
 Alvarez-Larràn et al19  2018 Comparison of ruxolitinib and real-world best available therapy in terms of overall survival and thrombosis in patients with polycythemia vera who are resistant or intolerant to hydroxyurea. HemaSphere 
 Kiladjian et al28  2018 Efficacy and safety of ruxolitinib after and versus interferon use in the RESPONSE studies. Annals of Hematology 
 Kiladjian et al20  2018 Long-term efficacy and safety (5 years) in RESPONSE, a phase 3 study comparing ruxolitinib (RUX) with best available therapy (BAT) in hydroxyurea (HU)-resistant/intolerant patients (pts) with polycythemia vera (PV). Blood 
RESPONSE-2 Passamonti et al14  2016 Ruxolitinib proves superior to best available therapy in patients with polycythemia vera (PV) and a nonpalpable spleen: results from the phase IIIb RESPONSE-2 study. Haematologica 
 Passamonti et al 2017 Ruxolitinib for the treatment of inadequately controlled polycythaemia vera without splenomegaly (RESPONSE-2): a randomized, open-label, phase 3b study. The Lancet Oncology 
 Passamonti et al29  2018 Ruxolitinib for the treatment of inadequately controlled polycythemia vera without splenomegaly: 156-week follow-up from the phase 3 RESPONSE-2 study. Blood 
 Griesshammer et al 2018 Ruxolitinib for the treatment of inadequately controlled polycythemia vera without splenomegaly: 80-week follow-up from the RESPONSE-2 trial. Annals of Hematology 
MAJIC Harrison et al12  2018 Ruxolitinib compared with best available therapy for polycythaemia vera patients resistant or intolerant to hydroxycarbamide in MAJIC—an investigator-led randomised trial. HemaSphere 
 Curto-Garcia et al13  2019 Molecular analysis in MAJIC PV correlation with clinical endpoints. HemaSphere 
RELIEF Mesa et al10  2017 The efficacy and safety of continued hydroxycarbamide therapy versus switching to ruxolitinib in patients with polycythaemia vera: a randomized, double-blind, double-dummy, symptom study (RELIEF). British Journal of Haematology 
Clinical trialAuthorYearTitleJournal
RESPONSE Verstovsek et al24  2014 Results of a prospective, randomized, open-label phase 3 study of ruxolitinib (RUX) in polycythemia vera (PV) patients resistant to or intolerant of hydroxyurea (HU) the RESPONSE trial. Journal of Clinical Oncology 
 Vannucchi et al25  2014 Ruxolitinib proves superior to best available therapy in a prospective, randomized, phase 3 study (RESPONSE) in patients with polycythemia vera resistant to or intolerant of hydroxyurea. Haematologica 
 Vannucchi et al 2015 Ruxolitinib versus standard therapy for the treatment of polycythemia vera. The New England Journal of Medicine 
 Verstovsek et al26  2015 Safety of ruxolitinib in patients with polycythemia vera Results from the clinical trial program. Haematologica 
 Verstovsek et al 2016 Ruxolitinib versus best available therapy in patients with polycythemia vera: 80-week follow-up from the RESPONSE trial. Haematologica 
 Kiladjian et al27  2017 Results from the 208-week (4-year) follow-up of RESPONSE trial, a phase 3 study comparing ruxolitinib (Rux) with best available therapy (BAT) for the treatment of polycythemia vera (PV). Blood 
 Alvarez-Larràn et al19  2018 Comparison of ruxolitinib and real-world best available therapy in terms of overall survival and thrombosis in patients with polycythemia vera who are resistant or intolerant to hydroxyurea. HemaSphere 
 Kiladjian et al28  2018 Efficacy and safety of ruxolitinib after and versus interferon use in the RESPONSE studies. Annals of Hematology 
 Kiladjian et al20  2018 Long-term efficacy and safety (5 years) in RESPONSE, a phase 3 study comparing ruxolitinib (RUX) with best available therapy (BAT) in hydroxyurea (HU)-resistant/intolerant patients (pts) with polycythemia vera (PV). Blood 
RESPONSE-2 Passamonti et al14  2016 Ruxolitinib proves superior to best available therapy in patients with polycythemia vera (PV) and a nonpalpable spleen: results from the phase IIIb RESPONSE-2 study. Haematologica 
 Passamonti et al 2017 Ruxolitinib for the treatment of inadequately controlled polycythaemia vera without splenomegaly (RESPONSE-2): a randomized, open-label, phase 3b study. The Lancet Oncology 
 Passamonti et al29  2018 Ruxolitinib for the treatment of inadequately controlled polycythemia vera without splenomegaly: 156-week follow-up from the phase 3 RESPONSE-2 study. Blood 
 Griesshammer et al 2018 Ruxolitinib for the treatment of inadequately controlled polycythemia vera without splenomegaly: 80-week follow-up from the RESPONSE-2 trial. Annals of Hematology 
MAJIC Harrison et al12  2018 Ruxolitinib compared with best available therapy for polycythaemia vera patients resistant or intolerant to hydroxycarbamide in MAJIC—an investigator-led randomised trial. HemaSphere 
 Curto-Garcia et al13  2019 Molecular analysis in MAJIC PV correlation with clinical endpoints. HemaSphere 
RELIEF Mesa et al10  2017 The efficacy and safety of continued hydroxycarbamide therapy versus switching to ruxolitinib in patients with polycythaemia vera: a randomized, double-blind, double-dummy, symptom study (RELIEF). British Journal of Haematology 
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