Table 3.

Syndromic approach to the clinical presentation of MGRS

Clinical syndrome/presentationAssociated MGRS entities
NS Amyloidosis (glomerular), MIDD 
Nephritic-nephrotic syndrome (proteinuria, hematuria, hypertension, low complement levels, and renal insufficiency) PGNMID, ITG, FG, C3G with monoclonal immunoglobulin, cryoglobulinemic GN 
Acute renal failure TMA, MIDD, and crystalglobulinemia 
Proteinuria/progressive renal insufficiency LCPT (with/without FS), MIDD, amyloidosis (tubulointerstitial and vascular), CSH, TMA 
Clinical syndrome/presentationAssociated MGRS entities
NS Amyloidosis (glomerular), MIDD 
Nephritic-nephrotic syndrome (proteinuria, hematuria, hypertension, low complement levels, and renal insufficiency) PGNMID, ITG, FG, C3G with monoclonal immunoglobulin, cryoglobulinemic GN 
Acute renal failure TMA, MIDD, and crystalglobulinemia 
Proteinuria/progressive renal insufficiency LCPT (with/without FS), MIDD, amyloidosis (tubulointerstitial and vascular), CSH, TMA 

Adapted from Sethi et al29  with permission.

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