Classification of MGRS entities based on presence and site of deposition of monoclonal proteins in renal structures
| MGRS with monoclonal protein deposition in renal structures . | ||
|---|---|---|
| Glomerular deposition . | Tubulointerstitial deposition . | Intrarenal vascular deposition . |
| Amyloidosis (AL/AH/AHL) | LCPT with and without crystals | Amyloidosis |
| Monoclonal fibrillary glomerulopathy | CSH | Crystalglobulinemia |
| Immunotactoid glomerulopathy | Amyloidosis | MIDD |
| Cryoglobulinemic GN (types I and II) | MIDD | Cryoglobulinemic GN (types I and II) |
| MIDD (LCDD/HCDD/HLDD) | ||
| PGNMID | ||
| MPGN associated with monoclonal immunoglobulin | ||
| MN secondary to monoclonal immunoglobulin | ||
| MGRS with monoclonal protein deposition in renal structures . | ||
|---|---|---|
| Glomerular deposition . | Tubulointerstitial deposition . | Intrarenal vascular deposition . |
| Amyloidosis (AL/AH/AHL) | LCPT with and without crystals | Amyloidosis |
| Monoclonal fibrillary glomerulopathy | CSH | Crystalglobulinemia |
| Immunotactoid glomerulopathy | Amyloidosis | MIDD |
| Cryoglobulinemic GN (types I and II) | MIDD | Cryoglobulinemic GN (types I and II) |
| MIDD (LCDD/HCDD/HLDD) | ||
| PGNMID | ||
| MPGN associated with monoclonal immunoglobulin | ||
| MN secondary to monoclonal immunoglobulin | ||
| MGRS without monoclonal protein deposition in renal structures . | ||
|---|---|---|
| Glomerular involvement . | Tubulointerstitial involvement . | Intrarenal vascular involvement . |
| C3GN | TMA | |
| TMA | POEMS syndrome | |
| POEMS syndrome | ||
| MGRS without monoclonal protein deposition in renal structures . | ||
|---|---|---|
| Glomerular involvement . | Tubulointerstitial involvement . | Intrarenal vascular involvement . |
| C3GN | TMA | |
| TMA | POEMS syndrome | |
| POEMS syndrome | ||
AH, heavy chain amyloidosis; AHL, heavy and light chain amyloidosis; AL, light chain amyloidosis; C3GN, C3 glomerulonephritis; CSH, crystal-storing histiocytosis; HCDD, heavy chain deposition disease; HLDD, heavy and light chain deposition disease; LCDD, light chain deposition disease; LCPT, light chain proximal tubulopathy; MN, membranous nephropathy; POEMS, polyneuropathy organomegaly endocrinopathy monoclonal gammopathy, and skin changes.
Adapted from Ciocchini et al5 with permission.