Patient characteristics for discovery and validation cohorts
| Variable . | Discovery cohort (n = 96) . | Validation cohort (n = 88) . | P . |
|---|---|---|---|
| Age, y | .669 | ||
| Median | 48 | 50.5 | |
| Range | 17-77 | 17-80 | |
| Sex | .552 | ||
| Female | 38 (39.6) | 39 (44.3) | |
| Male | 58 (60.4) | 49 (55.7) | |
| BCR-ABL1 at 3 mo, % | 1 | ||
| <10 | 83 (86.5) | 77 (87.5) | |
| >10 | 13 (13.5) | 11 (12.5) | |
| BCR-ABL1 transcript type | .084 | ||
| b2a2 | 38 (39.6) | 36 (40.9) | |
| b2a3 | 1 (1.0) | 0 (0.0) | |
| b3a2 | 32 (33.3) | 39 (44.3) | |
| Both | 25 (26.0) | 12 (13.6) | |
| e1a2 | 0 (0.0) | 1 (1.1) | |
| Sokal score | .458 | ||
| High | 15 (16.9) | 19 (21.8) | |
| Intermediate | 27 (30.3) | 30 (34.5) | |
| Low | 47 (52.8) | 38 (43.7) | |
| ELTS | .442 | ||
| High | 7 (7.9) | 12 (13.8) | |
| Intermediate | 23 (25.8) | 20 (23.0) | |
| Low | 59 (66.3) | 55 (63.2) | |
| BC progression | .447 | ||
| Yes | 5 (5.2) | 2 (2.3) | |
| No | 91 (94.8) | 86 (97.7) | |
| MMR by 24 mo | .279 | ||
| Yes | 79 (82.3) | 66 (75.0) | |
| No | 17 (17.7) | 22 (25.0) | |
| MR4.5 by 5 y | .298 | ||
| Yes | 59 (61.5) | 47 (53.4) | |
| No | 37 (38.5) | 41 (46.6) |
| Variable . | Discovery cohort (n = 96) . | Validation cohort (n = 88) . | P . |
|---|---|---|---|
| Age, y | .669 | ||
| Median | 48 | 50.5 | |
| Range | 17-77 | 17-80 | |
| Sex | .552 | ||
| Female | 38 (39.6) | 39 (44.3) | |
| Male | 58 (60.4) | 49 (55.7) | |
| BCR-ABL1 at 3 mo, % | 1 | ||
| <10 | 83 (86.5) | 77 (87.5) | |
| >10 | 13 (13.5) | 11 (12.5) | |
| BCR-ABL1 transcript type | .084 | ||
| b2a2 | 38 (39.6) | 36 (40.9) | |
| b2a3 | 1 (1.0) | 0 (0.0) | |
| b3a2 | 32 (33.3) | 39 (44.3) | |
| Both | 25 (26.0) | 12 (13.6) | |
| e1a2 | 0 (0.0) | 1 (1.1) | |
| Sokal score | .458 | ||
| High | 15 (16.9) | 19 (21.8) | |
| Intermediate | 27 (30.3) | 30 (34.5) | |
| Low | 47 (52.8) | 38 (43.7) | |
| ELTS | .442 | ||
| High | 7 (7.9) | 12 (13.8) | |
| Intermediate | 23 (25.8) | 20 (23.0) | |
| Low | 59 (66.3) | 55 (63.2) | |
| BC progression | .447 | ||
| Yes | 5 (5.2) | 2 (2.3) | |
| No | 91 (94.8) | 86 (97.7) | |
| MMR by 24 mo | .279 | ||
| Yes | 79 (82.3) | 66 (75.0) | |
| No | 17 (17.7) | 22 (25.0) | |
| MR4.5 by 5 y | .298 | ||
| Yes | 59 (61.5) | 47 (53.4) | |
| No | 37 (38.5) | 41 (46.6) |
Data are n (%) unless otherwise noted.