Variants associated with transient ITP, compared with chronic ITP
| . | Transient ITP (self-limiting or IVIg-responsive) TIKI (N = 131) . | Chronic ITP (CINKID & TIKI; N = 43) . | P . | P (FDR adjusted) . | OR (95% CI) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 . | 1 . | 2 . | 3 . | 4 . | 0 . | 1 . | 2 . | 3 . | 4 . | ||||
| CNV | |||||||||||||
| CNR1 | 0 (0) | 4 (3) | 118 (90) | 9 (7) | 0 (0) | 0 (0) | 7 (16) | 33 (77) | 3 (7) | 0 (0) | .011 | .11 | 6.2 (1.8-24.7)* |
| CNR2 | 0 (0) | 0 (0) | 126 (96) | 5 (4) | 0 (0) | 0 (0) | 1 (2) | 42 (98) | 0 (0) | 0 (0) | .09 | .45 | |
| CNR3 | 0 (0) | 0 (0) | 131 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 43 (100) | 0 (0) | 0 (0) | ND | ND | |
| Alleles | |||||||||||||
| FCGR2A*27W | 88 (67) | 39 (30) | 4 (3) | 0 (0) | 0 (0) | 37 (86) | 5 (12) | 1 (2) | 0 (0) | 0 (0) | .041 | .37 | 3.3 (1.3-10.1)† |
| FCGR2A*131H | 27 (21) | 68 (52) | 36 (27) | 0 (0) | 0 (0) | 11 (26) | 18 (42) | 14 (33) | 0 (0) | 0 (0) | .50 | .37 | |
| FCGR2B*232T | 98 (75) | 30 (23) | 3 (2) | 0 (0) | 0 (0) | 31 (72) | 10 (23) | 2 (5) | 0 (0) | 0 (0) | .72 | 1.0 | |
| FCGR2C*ORF | 81 (62) | 48 (37) | 2 (2) | 0 (0) | 0 (0) | 38 (88) | 5 (12) | 0 (0) | 0 (0) | 0 (0) | .002 | .022 | 4.7 (1.9-14.3)‡ |
| FCGR2C*ncORF | 125 (95) | 3 (2) | 3 (2) | 0 (0) | 0 (0) | 38 (88) | 2 (5) | 3 (7) | 0 (0) | 0 (0) | .19 | .57 | |
| FCGR3A*158V | 46 (35) | 63 (48) | 22 (17) | 0 (0) | 0 (0) | 13 (30) | 22 (51) | 8 (19) | 0 (0) | 0 (0) | .87 | 1.0 | |
| FCGR3B*NA2 | 11 (8) | 66 (50) | 54 (42) | 0 (0) | 0 (0) | 9 (21) | 18 (42) | 16 (37) | 0 (0) | 0 (0) | .10 | .45 | |
| FCGR3B*SH | 128 (98) | 3 (2) | 0 (0) | 0 (0) | 0 (0) | 39 (91) | 4 (9) | 0 (0) | 0 (0) | 0 (0) | .06 | .37 | |
| FCGR2 promoter 2B.4 | 92 (70) | 39 (30) | 0 (0) | 0 (0) | 0 (0) | 37 (86) | 6 (14) | 0 (0) | 0 (0) | 0 (0) | .045 | .37 | 2.6 (1.1-7.3)‡ |
| . | Transient ITP (self-limiting or IVIg-responsive) TIKI (N = 131) . | Chronic ITP (CINKID & TIKI; N = 43) . | P . | P (FDR adjusted) . | OR (95% CI) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 . | 1 . | 2 . | 3 . | 4 . | 0 . | 1 . | 2 . | 3 . | 4 . | ||||
| CNV | |||||||||||||
| CNR1 | 0 (0) | 4 (3) | 118 (90) | 9 (7) | 0 (0) | 0 (0) | 7 (16) | 33 (77) | 3 (7) | 0 (0) | .011 | .11 | 6.2 (1.8-24.7)* |
| CNR2 | 0 (0) | 0 (0) | 126 (96) | 5 (4) | 0 (0) | 0 (0) | 1 (2) | 42 (98) | 0 (0) | 0 (0) | .09 | .45 | |
| CNR3 | 0 (0) | 0 (0) | 131 (100) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 43 (100) | 0 (0) | 0 (0) | ND | ND | |
| Alleles | |||||||||||||
| FCGR2A*27W | 88 (67) | 39 (30) | 4 (3) | 0 (0) | 0 (0) | 37 (86) | 5 (12) | 1 (2) | 0 (0) | 0 (0) | .041 | .37 | 3.3 (1.3-10.1)† |
| FCGR2A*131H | 27 (21) | 68 (52) | 36 (27) | 0 (0) | 0 (0) | 11 (26) | 18 (42) | 14 (33) | 0 (0) | 0 (0) | .50 | .37 | |
| FCGR2B*232T | 98 (75) | 30 (23) | 3 (2) | 0 (0) | 0 (0) | 31 (72) | 10 (23) | 2 (5) | 0 (0) | 0 (0) | .72 | 1.0 | |
| FCGR2C*ORF | 81 (62) | 48 (37) | 2 (2) | 0 (0) | 0 (0) | 38 (88) | 5 (12) | 0 (0) | 0 (0) | 0 (0) | .002 | .022 | 4.7 (1.9-14.3)‡ |
| FCGR2C*ncORF | 125 (95) | 3 (2) | 3 (2) | 0 (0) | 0 (0) | 38 (88) | 2 (5) | 3 (7) | 0 (0) | 0 (0) | .19 | .57 | |
| FCGR3A*158V | 46 (35) | 63 (48) | 22 (17) | 0 (0) | 0 (0) | 13 (30) | 22 (51) | 8 (19) | 0 (0) | 0 (0) | .87 | 1.0 | |
| FCGR3B*NA2 | 11 (8) | 66 (50) | 54 (42) | 0 (0) | 0 (0) | 9 (21) | 18 (42) | 16 (37) | 0 (0) | 0 (0) | .10 | .45 | |
| FCGR3B*SH | 128 (98) | 3 (2) | 0 (0) | 0 (0) | 0 (0) | 39 (91) | 4 (9) | 0 (0) | 0 (0) | 0 (0) | .06 | .37 | |
| FCGR2 promoter 2B.4 | 92 (70) | 39 (30) | 0 (0) | 0 (0) | 0 (0) | 37 (86) | 6 (14) | 0 (0) | 0 (0) | 0 (0) | .045 | .37 | 2.6 (1.1-7.3)‡ |
Data are n (% of cohort). Bold values denote statistically significant P values. Chronic ITP was defined as absence of complete response (platelet count >100 × 109/L) 12 months after diagnosis. Transient ITP was defined as spontaneous recovery or a favorable response to IVIg 3 months after diagnosis. Patients from the TIKI trial with persistent ITP (recovery between 3 and 12 months) were excluded.
OR given for chronic ITP.
OR given for comparison of 27Q/W vs 27Q/W in association with transient ITP.
OR given for presence of 1 or 2 copies vs absence of the variant in association with transient ITP.