Patient characteristics by DE status, DH status, or other
| Characteristic . | Other* (N = 171) . | DE (N = 33)† . | DH (N = 7) . | P . |
|---|---|---|---|---|
| Age | ||||
| Median (range), y | 62 (19-89) | 62 (35-84) | 65 (44-77) | |
| >60 y | 96 (56) | 19 (58) | 4 (57) | 1.000 |
| Sex | ||||
| Male | 89 (52) | 11 (33) | 3 (43) | .128 |
| Stage at diagnosis | ||||
| I | 97 (57) | 26 (79) | 3 (43) | .030 |
| II | 74 (43) | 7 (21) | 4 (57) | |
| Poor performance status | ||||
| ECOG >1 | 24 (14) | 4 (12) | 0 (0) | .831 |
| LDH > ULN | 44 (31) | 10 (37) | 3 (50) | .418 |
| Extranodal sites–any | 91 (53) | 21 (64) | 3 (43) | .458 |
| >1 | 5 (3) | 0 (0) | 0 (0) | |
| Supradiaphragmatic | 103 (60) | 22 (67) | 3 (43) | .517 |
| Ki67, median (range) | 80 (15-100) | 82 (25-95) | 85 (40-90) | .337 |
| Bulk >7.5 cm | 33 (21) | 5 (18) | 4 (57) | .075 |
| COO | ||||
| GCB | 99 (65) | 13 (39) | 4 (57) | .019 |
| Non-GCB | 53 (35) | 20 (61) | 3 (43) | |
| Stage-modified IPI | ||||
| Low (0-1 point) | 71 (51) | 19 (73) | 3 (50) | .180 |
| Intermediate (2 points) | 41 (30) | 3 (12) | 1 (17) | |
| High (3-4 points) | 27 (19) | 4 (15) | 2 (33) |
| Characteristic . | Other* (N = 171) . | DE (N = 33)† . | DH (N = 7) . | P . |
|---|---|---|---|---|
| Age | ||||
| Median (range), y | 62 (19-89) | 62 (35-84) | 65 (44-77) | |
| >60 y | 96 (56) | 19 (58) | 4 (57) | 1.000 |
| Sex | ||||
| Male | 89 (52) | 11 (33) | 3 (43) | .128 |
| Stage at diagnosis | ||||
| I | 97 (57) | 26 (79) | 3 (43) | .030 |
| II | 74 (43) | 7 (21) | 4 (57) | |
| Poor performance status | ||||
| ECOG >1 | 24 (14) | 4 (12) | 0 (0) | .831 |
| LDH > ULN | 44 (31) | 10 (37) | 3 (50) | .418 |
| Extranodal sites–any | 91 (53) | 21 (64) | 3 (43) | .458 |
| >1 | 5 (3) | 0 (0) | 0 (0) | |
| Supradiaphragmatic | 103 (60) | 22 (67) | 3 (43) | .517 |
| Ki67, median (range) | 80 (15-100) | 82 (25-95) | 85 (40-90) | .337 |
| Bulk >7.5 cm | 33 (21) | 5 (18) | 4 (57) | .075 |
| COO | ||||
| GCB | 99 (65) | 13 (39) | 4 (57) | .019 |
| Non-GCB | 53 (35) | 20 (61) | 3 (43) | |
| Stage-modified IPI | ||||
| Low (0-1 point) | 71 (51) | 19 (73) | 3 (50) | .180 |
| Intermediate (2 points) | 41 (30) | 3 (12) | 1 (17) | |
| High (3-4 points) | 27 (19) | 4 (15) | 2 (33) |
Unless otherwise noted, all data are n (%). Bold indicates statistically significant results.
ECOG, Eastern Cooperative Oncology Group; IPI, International Prognostic Index; LDH, lactate dehydrogenase; ULN, upper limit of normal.
Sufficient IHC/FISH in 59 cases for full DH/DE assessment.
Excludes DH cases.