Table 4.

Trametinib pharmacokinetic parameters

Cycle 1, day 1Cycle 2, day 1
tmax, hCmax, ng/mLAUC6h, ng⋅h/mLtmax, hCmax, ng/mLAUC6h, ng⋅h/mL
n 10 10 10 6 6 3 
Mean NC 8.93 27.7 NC 28.0 120 
SD NC 3.34 10.1 NC 9.81 17.1 
Cycle 1, day 1Cycle 2, day 1
tmax, hCmax, ng/mLAUC6h, ng⋅h/mLtmax, hCmax, ng/mLAUC6h, ng⋅h/mL
n 10 10 10 6 6 3 
Mean NC 8.93 27.7 NC 28.0 120 
SD NC 3.34 10.1 NC 9.81 17.1 
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