Subgroup analysis for OS from diagnosis in patients with acquired del(17p) and controls based on prognostic factors at diagnosis and therapy
| Subgroup . | No. of patients with available data in the subgroups . | Acquired del(17p) (n = 76) . | Controls (n = 152) . | P* . |
|---|---|---|---|---|
| Age, y | ||||
| <65 | 48 vs 101 | 72.3 (49.6-99.0) | 106.1 (98.5-127.8) | .002 |
| ≥65 | 28 vs 51 | 58.2 (44.1-71.3) | 105.9 (68.6-138.8) | <.001 |
| Translocation | ||||
| High risk | 14 vs 14 | 56.8 (24.0-119.0) | 98.3 (60.5-111.8) | .419 |
| No high risk | 62 vs 138 | 68.9 (50.8-74.8) | 111.7 (103.4-129.3) | <.001 |
| ISS | ||||
| I/II | 42 vs 110 | 71.3 (50.8-75.4) | 106.1 (101.6-129.3) | <.001 |
| III | 14 vs 26 | 44.4 (13.8-103.1) | 104.8 (60.7-111.8) | .036 |
| LDH | ||||
| Low | 44 vs 116 | 63.8 (44.6-99.0) | 105.9 (98.5-119.4) | .004 |
| High | 7 vs 5 | 55.5 (23.2-86.4) | 100.9 (80.6-NR) | .011 |
| PC proliferative rate | ||||
| Low | 31 vs 84 | 74.6 (58.3-99.0) | 106.1 (98.3-137.8) | .025 |
| High | 14 vs 24 | 42.2 (24.0-103.1) | 103.4 (67.1-NR) | .031 |
| PI-containing induction | 21 vs 37 | 34.5 (24.0-50.8) | 104.8 (70.2-137.8) | <.001 |
| Others | 55 vs 115 | 74.6 (63.8-96.5) | 106.1 (98.5-127.8) | .003 |
| Subgroup . | No. of patients with available data in the subgroups . | Acquired del(17p) (n = 76) . | Controls (n = 152) . | P* . |
|---|---|---|---|---|
| Age, y | ||||
| <65 | 48 vs 101 | 72.3 (49.6-99.0) | 106.1 (98.5-127.8) | .002 |
| ≥65 | 28 vs 51 | 58.2 (44.1-71.3) | 105.9 (68.6-138.8) | <.001 |
| Translocation | ||||
| High risk | 14 vs 14 | 56.8 (24.0-119.0) | 98.3 (60.5-111.8) | .419 |
| No high risk | 62 vs 138 | 68.9 (50.8-74.8) | 111.7 (103.4-129.3) | <.001 |
| ISS | ||||
| I/II | 42 vs 110 | 71.3 (50.8-75.4) | 106.1 (101.6-129.3) | <.001 |
| III | 14 vs 26 | 44.4 (13.8-103.1) | 104.8 (60.7-111.8) | .036 |
| LDH | ||||
| Low | 44 vs 116 | 63.8 (44.6-99.0) | 105.9 (98.5-119.4) | .004 |
| High | 7 vs 5 | 55.5 (23.2-86.4) | 100.9 (80.6-NR) | .011 |
| PC proliferative rate | ||||
| Low | 31 vs 84 | 74.6 (58.3-99.0) | 106.1 (98.3-137.8) | .025 |
| High | 14 vs 24 | 42.2 (24.0-103.1) | 103.4 (67.1-NR) | .031 |
| PI-containing induction | 21 vs 37 | 34.5 (24.0-50.8) | 104.8 (70.2-137.8) | <.001 |
| Others | 55 vs 115 | 74.6 (63.8-96.5) | 106.1 (98.5-127.8) | .003 |
NR, not reached.
P for log-rank test for Kaplan-Meier analysis.