Univariable analysis of factors that may predict severe Cfz-induced CVAEs
| Variables . | Univariate analysis . | |
|---|---|---|
| Odds ratio (95% CI) . | P . | |
| Background and/or frailty parameters | ||
| Age ≥70 y | 1.20 (0.35-4.30) | .75 |
| Male sex | 1.14 (0.33-3.95) | .83 |
| ECOG-PS ≥3 | 5.98 (1.59-22.4) | .008 |
| Cardiovascular risk factors | ||
| Smoking | 1.83 (0.52-6.43) | .34 |
| Coronary artery disease | 5.80 (0.73-46.0) | .096 |
| Chronic heart failure | 6.33 (1.10-36.4) | .038 |
| Hypertension | 0.46 (0.12-1.72) | .25 |
| Diabetes mellitus | 1.00 (0.23-4.18) | 1.0 |
| Hyperlipidemia | 1.10 (0.26-4.61) | .90 |
| Hyperuricemia | 0.59 (0.06-5.22) | .63 |
| Stroke | 1.27 (0.13-12.5) | .83 |
| Myeloma-related factors | ||
| AL amyloidosis | 5.80 (0.73-46.0) | .096 |
| Progressive disease | 2.75 (0.77-9.77) | .12 |
| Prior high-dose therapy followed by ASCT | 0.84 (0.20-3.50) | .81 |
| More than 3 prior treatments | 5.06 (1.34-19.0) | .016 |
| Cfz-containing regimen, KRd/Kd | 1.00 (0.11-9.42) | 1.0 |
| Cardiologic parameters | ||
| LV systolic dysfunction | 2.64 (0.22-31.7) | .44 |
| Definite LVDD | 13.4 (3.10-57.6) | <.001 |
| Variables . | Univariate analysis . | |
|---|---|---|
| Odds ratio (95% CI) . | P . | |
| Background and/or frailty parameters | ||
| Age ≥70 y | 1.20 (0.35-4.30) | .75 |
| Male sex | 1.14 (0.33-3.95) | .83 |
| ECOG-PS ≥3 | 5.98 (1.59-22.4) | .008 |
| Cardiovascular risk factors | ||
| Smoking | 1.83 (0.52-6.43) | .34 |
| Coronary artery disease | 5.80 (0.73-46.0) | .096 |
| Chronic heart failure | 6.33 (1.10-36.4) | .038 |
| Hypertension | 0.46 (0.12-1.72) | .25 |
| Diabetes mellitus | 1.00 (0.23-4.18) | 1.0 |
| Hyperlipidemia | 1.10 (0.26-4.61) | .90 |
| Hyperuricemia | 0.59 (0.06-5.22) | .63 |
| Stroke | 1.27 (0.13-12.5) | .83 |
| Myeloma-related factors | ||
| AL amyloidosis | 5.80 (0.73-46.0) | .096 |
| Progressive disease | 2.75 (0.77-9.77) | .12 |
| Prior high-dose therapy followed by ASCT | 0.84 (0.20-3.50) | .81 |
| More than 3 prior treatments | 5.06 (1.34-19.0) | .016 |
| Cfz-containing regimen, KRd/Kd | 1.00 (0.11-9.42) | 1.0 |
| Cardiologic parameters | ||
| LV systolic dysfunction | 2.64 (0.22-31.7) | .44 |
| Definite LVDD | 13.4 (3.10-57.6) | <.001 |
CI, confidence interval.