Table 1. Echocardiography analyses of... | American Society of Hematology

Table 1.

Echocardiography analyses of the experimental mice

Parameter	Fib^WT AA/B6	Fibγ^390-396A AA/B6	Fib^WT SS	Fibγ^390-396A SS
IVS;d, mm	0.80 ± 0.05	0.84 ± 0.05	0.91 ± 0.05	0.83 ± 0.08
LVPW;d, mm	0.80 ± 0.04	0.81 ± 0.04	0.84 ± 0.04	0.77 ± 0.05
LA, mm	2.2 ± 0.6	2.5 ± 0.1	3.2 ± 0.2*†	2.8 ± 0.2
MV E, cm/s	645 ± 33	645 ± 62	730 ± 74	689 ± 56
MV LW E′, cm/s	22 ± 3	21 ± 2	31 ± 6	20 ± 3
MV E/LW E′	32 ± 3	32 ± 4	31 ± 4	39 ± 8
Heart rate, bpm	344 ± 31	330 ± 27	372 ± 31	383 ± 26

Parameter	Fib^WT AA/B6	Fibγ^390-396A AA/B6	Fib^WT SS	Fibγ^390-396A SS
IVS;d, mm	0.80 ± 0.05	0.84 ± 0.05	0.91 ± 0.05	0.83 ± 0.08
LVPW;d, mm	0.80 ± 0.04	0.81 ± 0.04	0.84 ± 0.04	0.77 ± 0.05
LA, mm	2.2 ± 0.6	2.5 ± 0.1	3.2 ± 0.2*†	2.8 ± 0.2
MV E, cm/s	645 ± 33	645 ± 62	730 ± 74	689 ± 56
MV LW E′, cm/s	22 ± 3	21 ± 2	31 ± 6	20 ± 3
MV E/LW E′	32 ± 3	32 ± 4	31 ± 4	39 ± 8
Heart rate, bpm	344 ± 31	330 ± 27	372 ± 31	383 ± 26

Echocardiograms were performed 12 months post-BMT. Similar numbers of fully chimeric male and female mice were used in the experimental groups. Data are presented as mean plus or minus SEM. Statistical significance was determined using 1-way ANOVA followed by the Tukey's multiple comparison test.

bpm, beats per minute; LW E′, lateral wall mitral valve tissue Doppler E wave; MV E, mitral valve early filling.

P ≤ .01 vs Fib^WT AA/B6.

†

P ≤ .05 vs Fibγ^390-396A AA/B6.

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