Table 2. Characteristics of randomized... | American Society of Hematology

Table 2.

Characteristics of randomized patients with and without DS

	DS			Total DS, n = 75	Non-DS, n = 2003	P*
	PO MTX, n = 44	IV MTX, n = 31	P*	Total DS, n = 75	Non-DS, n = 2003	P*
Age at diagnosis, y
<2	2	0	.33	2	184	.07
2-5	32	20		52	1393
6-9	10	11		21	426
Sex
Female	24	13	.28	37	1110	.30
Male	20	18		38	893
WBC
<20 × 10⁹/L	36	29	.18	65	1659	.39
≥20 × 10⁹/L	8	2		10	343
Unknown/missing	0	0		0	1
CNS status
CNS-1	39	27	.64	66	1772	.99
CNS-2	2	1		3	99
CNS-3	0	0		0	5
Unknown/missing	3	3		6	127
Cytogenetics
ETV6-RUNX1†	1	0	.99	1	357	<.001
Double trisomies 4 and 10‡	5	1	.39	6	244	.27
BM day 7
M1	28	18	.64	46	900	.016
M2	6	7		13	599
M3	8	6		14	424
Uninterpretable	2	0		2	35
Not done/missing	0	0		0	45
BM day 14
M1	18	13	—	31	1065	.99
M2	0	0		0	31
M3	0	0		0	0
Uninterpretable	0	0		0	1
Not done/missing	26	18		44	905

	DS			Total DS, n = 75	Non-DS, n = 2003	P*
	PO MTX, n = 44	IV MTX, n = 31	P*	Total DS, n = 75	Non-DS, n = 2003	P*
Age at diagnosis, y
<2	2	0	.33	2	184	.07
2-5	32	20		52	1393
6-9	10	11		21	426
Sex
Female	24	13	.28	37	1110	.30
Male	20	18		38	893
WBC
<20 × 10⁹/L	36	29	.18	65	1659	.39
≥20 × 10⁹/L	8	2		10	343
Unknown/missing	0	0		0	1
CNS status
CNS-1	39	27	.64	66	1772	.99
CNS-2	2	1		3	99
CNS-3	0	0		0	5
Unknown/missing	3	3		6	127
Cytogenetics
ETV6-RUNX1†	1	0	.99	1	357	<.001
Double trisomies 4 and 10‡	5	1	.39	6	244	.27
BM day 7
M1	28	18	.64	46	900	.016
M2	6	7		13	599
M3	8	6		14	424
Uninterpretable	2	0		2	35
Not done/missing	0	0		0	45
BM day 14
M1	18	13	—	31	1065	.99
M2	0	0		0	31
M3	0	0		0	0
Uninterpretable	0	0		0	1
Not done/missing	26	18		44	905

—, not calculated.

The χ² or Fisher's exact test was used after excluding unknown/missing/uninterpretable/not done groups.

Patients (n = 1041) were analyzed for the presence of ETV6-RUNX1 transcript.

Patients (n = 1330) were analyzed for the presence of trisomies 4 and 10.