MIR155HG expression is an IPI-independent prognostic marker for R-CHOP-treated patients with GCB-DLBCL
| . | n . | no. . | Simple . | Multiple . | ||||
|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |||
| All DLBCL | ||||||||
| miR-155 | ||||||||
| Low | 293 | 90 | 1 | — | ||||
| High | 293 | 107 | 1.17 | 0.88-1.54 | .28 | — | — | — |
| IPI | ||||||||
| 0-1 | 71 | 6 | 1 | 1 | ||||
| 2-3 | 314 | 84 | 3.76 | 1.64-8.61 | .0017 | 3.42 | 1.49-7.84 | .0038 |
| 4-5 | 201 | 106 | 9.61 | 4.22-21.88 | 7.19e-08 | 8.29 | 3.62-18.98 | 5.73e-07 |
| Subclass | ||||||||
| ABC | 242 | 105 | 1 | 1 | ||||
| GCB | 248 | 58 | 0.45 | 0.33-0.62 | 1.09e-06 | 0.55 | 0.40-0.76 | .00032 |
| UC | 96 | 34 | 0.73 | 0.50-1.08 | .11 | 0.71 | 0.48-1.05 | .089 |
| ABC-DLBCL | ||||||||
| miR-155 | ||||||||
| Low | 121 | 57 | 1 | — | ||||
| High | 121 | 48 | 0.78 | 0.53-1.14 | .20 | — | — | — |
| IPI | ||||||||
| 0-1 | 15 | 2 | 1 | — | ||||
| 2-3 | 125 | 38 | 3.57 | 0.86-14.89 | .080 | — | — | — |
| 4-5 | 102 | 65 | 10.37 | 2.51-42.87 | .0012 | — | — | — |
| GCB-DLBCL | ||||||||
| miR-155 | ||||||||
| Low | 124 | 41 | 1 | 1 | ||||
| High | 124 | 17 | 0.40 | 0.23-0.71 | .0017 | 0.46 | 0.26-0.81 | .0071 |
| IPI | ||||||||
| 0-1 | 48 | 2 | 1 | 1 | ||||
| 2-3 | 140 | 32 | 6.22 | 1.49-25.97 | .012 | 5.91 | 1.42-24.69 | .015 |
| 4-5 | 60 | 24 | 12.53 | 2.96-53.06 | .0006 | 11.10 | 2.61-47.15 | .0011 |
| . | n . | no. . | Simple . | Multiple . | ||||
|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |||
| All DLBCL | ||||||||
| miR-155 | ||||||||
| Low | 293 | 90 | 1 | — | ||||
| High | 293 | 107 | 1.17 | 0.88-1.54 | .28 | — | — | — |
| IPI | ||||||||
| 0-1 | 71 | 6 | 1 | 1 | ||||
| 2-3 | 314 | 84 | 3.76 | 1.64-8.61 | .0017 | 3.42 | 1.49-7.84 | .0038 |
| 4-5 | 201 | 106 | 9.61 | 4.22-21.88 | 7.19e-08 | 8.29 | 3.62-18.98 | 5.73e-07 |
| Subclass | ||||||||
| ABC | 242 | 105 | 1 | 1 | ||||
| GCB | 248 | 58 | 0.45 | 0.33-0.62 | 1.09e-06 | 0.55 | 0.40-0.76 | .00032 |
| UC | 96 | 34 | 0.73 | 0.50-1.08 | .11 | 0.71 | 0.48-1.05 | .089 |
| ABC-DLBCL | ||||||||
| miR-155 | ||||||||
| Low | 121 | 57 | 1 | — | ||||
| High | 121 | 48 | 0.78 | 0.53-1.14 | .20 | — | — | — |
| IPI | ||||||||
| 0-1 | 15 | 2 | 1 | — | ||||
| 2-3 | 125 | 38 | 3.57 | 0.86-14.89 | .080 | — | — | — |
| 4-5 | 102 | 65 | 10.37 | 2.51-42.87 | .0012 | — | — | — |
| GCB-DLBCL | ||||||||
| miR-155 | ||||||||
| Low | 124 | 41 | 1 | 1 | ||||
| High | 124 | 17 | 0.40 | 0.23-0.71 | .0017 | 0.46 | 0.26-0.81 | .0071 |
| IPI | ||||||||
| 0-1 | 48 | 2 | 1 | 1 | ||||
| 2-3 | 140 | 32 | 6.22 | 1.49-25.97 | .012 | 5.91 | 1.42-24.69 | .015 |
| 4-5 | 60 | 24 | 12.53 | 2.96-53.06 | .0006 | 11.10 | 2.61-47.15 | .0011 |
Array-based miR-155 expression and outcome were analyzed by simple and multiple Cox proportional hazards regression analyses for OS. IPI (international prognostic index) score information was not available for all patients, thus cohort sizes are reduced in this setting (115 samples were removed). MIR155HG expression was dichotomized by median split in each of the individual cohorts: all DLBCL patients, ABC-classified patients, and GCB-classified patients.
—, value not available because variables were only included in multiple Cox proportional hazards regression analysis if significant results were obtained in simple Cox proportional hazards regression analysis; CI, 95% lower and upper confidence intervals; HR, hazard ratio; n, number of samples; no., number of events.