Cytokine and immune modulatory molecule upregulation in mouse myeloma TEM following RV and BTZ combination treatment
| Sample . | IFN-β, no. + MNC/×200 (SD) . | IFN-γ, no. + MNC/×200 (SD) . | MHC1, no. + MNC/×200 (SD) . | TAP1, no. + MNC/×200 (SD) . | TLR3, no. + MNC/×200 (SD) . | NF-κB, no. + MNC/×200 (SD) . |
|---|---|---|---|---|---|---|
| Tumor-free control spleen | 0 | 0 | 12.3 (4.4) | 2.0 (0.7) | 0 | 1.1 (0.4) |
| Vehicle control myeloma spleen | 7.1* (1.3) | 15.2 (5.5) | 19.5 (4.0) | 4.1 (1.1) | 13.5 (2.3) | 12.2 (3.3) |
| DV myeloma spleen | 4.9 (2.0) | 11.9 (5.9) | 27.4 (7.9) | 12.2 (4.7) | 20.1 (6.3) | 32.9 (6.0) |
| BTZ myeloma spleen | 15.0 (6.6) | 23.2 (8.2) | 29.0 (7.7) | 5.0 (2.8) | 34.3 (7.7) | 33.9 (5.7) |
| DV + BTZ myeloma spleen | 18.1 (5.8) | 28.9 (9.0) | 25.2 (8.2) | 15.9 (3.3) | 27.9 (9.2) | 28.9 (7.1) |
| LV myeloma spleen (low productive infection) | 14.1 (4.9) | 18.8 (4.3) | 111.9 (9.7) | 48.9 (7.7) | 109.4 (9.2) | 69.5 (5.9) |
| LV + BTZ myeloma spleen (productive infection) | 83.2 (8.95) | 76.1 (7.9) | 218.15 (17.1) | 91.3 (9.65) | 116.0 (9.25) | 76.35 (7.1) |
| Sample . | IFN-β, no. + MNC/×200 (SD) . | IFN-γ, no. + MNC/×200 (SD) . | MHC1, no. + MNC/×200 (SD) . | TAP1, no. + MNC/×200 (SD) . | TLR3, no. + MNC/×200 (SD) . | NF-κB, no. + MNC/×200 (SD) . |
|---|---|---|---|---|---|---|
| Tumor-free control spleen | 0 | 0 | 12.3 (4.4) | 2.0 (0.7) | 0 | 1.1 (0.4) |
| Vehicle control myeloma spleen | 7.1* (1.3) | 15.2 (5.5) | 19.5 (4.0) | 4.1 (1.1) | 13.5 (2.3) | 12.2 (3.3) |
| DV myeloma spleen | 4.9 (2.0) | 11.9 (5.9) | 27.4 (7.9) | 12.2 (4.7) | 20.1 (6.3) | 32.9 (6.0) |
| BTZ myeloma spleen | 15.0 (6.6) | 23.2 (8.2) | 29.0 (7.7) | 5.0 (2.8) | 34.3 (7.7) | 33.9 (5.7) |
| DV + BTZ myeloma spleen | 18.1 (5.8) | 28.9 (9.0) | 25.2 (8.2) | 15.9 (3.3) | 27.9 (9.2) | 28.9 (7.1) |
| LV myeloma spleen (low productive infection) | 14.1 (4.9) | 18.8 (4.3) | 111.9 (9.7) | 48.9 (7.7) | 109.4 (9.2) | 69.5 (5.9) |
| LV + BTZ myeloma spleen (productive infection) | 83.2 (8.95) | 76.1 (7.9) | 218.15 (17.1) | 91.3 (9.65) | 116.0 (9.25) | 76.35 (7.1) |
SD, standard deviation; MNC, mononuclear cell.
All cell counts were done at the interface of myeloma cells and normal spleen and represent the number of positive cells at ×200. N = 2, mean of 10 fields (SD).