Multivariate analysis for PFS and OS
| . | PFS . | OS . | ||
|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Patients undergoing ASCT as part of first-line therapy | ||||
| ≥VGPR vs not | 1.1 (0.7-1.6) | .8 | 1.6 (0.9-2.9) | .1 |
| High-risk FISH | 1.7 (1.1-2.6) | .03 | 1.2 (1.1-4.4) | .04 |
| ISS stage III vs I/II | 1.5 (0.9-2.3) | .1 | 2.1 (1.02-4.2) | .04 |
| Triplet vs not | 0.9 (0.6-1.2) | .4 | 0.6 (0.4-1.2) | .1 |
| Creatinine ≥2 mg/dL | 1.1 (0.6-2.0) | .7 | 1.4 (0.6-3.1) | .4 |
| Disease type: light chain vs not | 1.0 (0.6-1.5) | .9 | 0.8 (0.4-1.5) | .5 |
| Age (continuous variable) | 1.1 (0.4-2.9) | .8 | 2.6 (0.6-12.5) | .2 |
| Patients not undergoing ASCT as part of first-line therapy | ||||
| ≥VGPR vs not | 1.2 (0.8-1.7) | .4 | 1.5 (1.0-2.4) | .07 |
| High-risk FISH | 1.6 (1.2-2.3) | .006 | 2.1 (1.4-3.2) | <.001 |
| ISS stage III vs I/II | 1.4 (1.0-1.9) | .08 | 1.4 (0.9-2.2) | .1 |
| Triplet vs not | 0.9 (0.7-1.2) | .5 | 0.7 (0.5-1.0) | .06 |
| Creatinine ≥2 mg/dL | 2.3 (1.4-3.9) | .002 | 1.9 (1.0-3.8) | .06 |
| Disease type: light chain vs not | 1.0 (0.7-1.5) | .9 | 1.0 (0.6-1.6) | .9 |
| Age (continuous variable), y | 1.0 (0.5-2.4) | .9 | 7.0 (2.1-23.8) | .002 |
| . | PFS . | OS . | ||
|---|---|---|---|---|
| . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Patients undergoing ASCT as part of first-line therapy | ||||
| ≥VGPR vs not | 1.1 (0.7-1.6) | .8 | 1.6 (0.9-2.9) | .1 |
| High-risk FISH | 1.7 (1.1-2.6) | .03 | 1.2 (1.1-4.4) | .04 |
| ISS stage III vs I/II | 1.5 (0.9-2.3) | .1 | 2.1 (1.02-4.2) | .04 |
| Triplet vs not | 0.9 (0.6-1.2) | .4 | 0.6 (0.4-1.2) | .1 |
| Creatinine ≥2 mg/dL | 1.1 (0.6-2.0) | .7 | 1.4 (0.6-3.1) | .4 |
| Disease type: light chain vs not | 1.0 (0.6-1.5) | .9 | 0.8 (0.4-1.5) | .5 |
| Age (continuous variable) | 1.1 (0.4-2.9) | .8 | 2.6 (0.6-12.5) | .2 |
| Patients not undergoing ASCT as part of first-line therapy | ||||
| ≥VGPR vs not | 1.2 (0.8-1.7) | .4 | 1.5 (1.0-2.4) | .07 |
| High-risk FISH | 1.6 (1.2-2.3) | .006 | 2.1 (1.4-3.2) | <.001 |
| ISS stage III vs I/II | 1.4 (1.0-1.9) | .08 | 1.4 (0.9-2.2) | .1 |
| Triplet vs not | 0.9 (0.7-1.2) | .5 | 0.7 (0.5-1.0) | .06 |
| Creatinine ≥2 mg/dL | 2.3 (1.4-3.9) | .002 | 1.9 (1.0-3.8) | .06 |
| Disease type: light chain vs not | 1.0 (0.7-1.5) | .9 | 1.0 (0.6-1.6) | .9 |
| Age (continuous variable), y | 1.0 (0.5-2.4) | .9 | 7.0 (2.1-23.8) | .002 |
Bold type indicates P < .05.