Table 2.

Baseline characteristics of patients treated for newly diagnosed BL in Lilongwe, Malawi, by initial treatment regimen

Total no. of patientsCHOP (n = 22)More intensive regimen (n = 9)P
No.%MedianRangeMeanSDNo.%MedianRangeMeanSD
Male sex 31 15 68     67     
Age, y 31   20 15-57     16 15-55   .65 
Body mass index, kg/m2 26     18.9 4.9     17.9 1.5 .65 
B symptoms 31 13 59     78     .43 
Ann Arbor stage III to IV 31 18 82     67     .38 
ECOG PS ≥2 31 13 59     33     .25 
aaIPI 28             
 1  24     28     
 2  43     43      
 3  33     28      
Central nervous system involvement 31 23         .27 
Bone marrow involvement 21 21     14     
Abdominal disease 31 14 64     67     
Bulky disease (>10 cm) 20 11 73     80     
HIV positive 31 41     33     
CD4 count, cells per μL 12   130 29-605     238 39-272   .78 
HIV viral load, detectable >400 copies per μL 12 44         .49 
White blood cells, ×109/L 31   7.2 2.8-20.3     7.4 2.1-11.7   .91 
Hemoglobin, g/dL 31   11.0 1.6-14.8     9.9 7.7-11.7   .13 
Platelets, ×109/L 31   314 139-859     438 157-635   .24 
Creatinine, mg/dL 29   0.6 0.3-2.4     0.5 0.4-1.7   .41 
Bilirubin, mg/dL 28   0.4 0.2-2.0     0.4 0.2-1.4   .72 
Albumin, g/dL 22     3.7 2.7-5.8     3.4 2.3-4.4 .38 
LDH ratio per ULN 28   2.2 0.4-20     2.2 1.0-5.1   .98 
LDH >2× ULN 28 14 33     71     1.0 
Total no. of patientsCHOP (n = 22)More intensive regimen (n = 9)P
No.%MedianRangeMeanSDNo.%MedianRangeMeanSD
Male sex 31 15 68     67     
Age, y 31   20 15-57     16 15-55   .65 
Body mass index, kg/m2 26     18.9 4.9     17.9 1.5 .65 
B symptoms 31 13 59     78     .43 
Ann Arbor stage III to IV 31 18 82     67     .38 
ECOG PS ≥2 31 13 59     33     .25 
aaIPI 28             
 1  24     28     
 2  43     43      
 3  33     28      
Central nervous system involvement 31 23         .27 
Bone marrow involvement 21 21     14     
Abdominal disease 31 14 64     67     
Bulky disease (>10 cm) 20 11 73     80     
HIV positive 31 41     33     
CD4 count, cells per μL 12   130 29-605     238 39-272   .78 
HIV viral load, detectable >400 copies per μL 12 44         .49 
White blood cells, ×109/L 31   7.2 2.8-20.3     7.4 2.1-11.7   .91 
Hemoglobin, g/dL 31   11.0 1.6-14.8     9.9 7.7-11.7   .13 
Platelets, ×109/L 31   314 139-859     438 157-635   .24 
Creatinine, mg/dL 29   0.6 0.3-2.4     0.5 0.4-1.7   .41 
Bilirubin, mg/dL 28   0.4 0.2-2.0     0.4 0.2-1.4   .72 
Albumin, g/dL 22     3.7 2.7-5.8     3.4 2.3-4.4 .38 
LDH ratio per ULN 28   2.2 0.4-20     2.2 1.0-5.1   .98 
LDH >2× ULN 28 14 33     71     1.0 
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