Multivariate analysis of risk factors for GRFS
| Variables . | CB . | MRD . | 1-MMRD . | MUD . | 1-MMUD . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Use of ATG* | ||||||||||
| ATG(−) | 1 | 1 | 1 | 1 | 1 | |||||
| ATG(+) | 1.458 (0.995-1.979) | .053 | 0.990 (0.530-1.851) | .95 | 0.915 (0.634-1.322) | .64 | 1.360 (0.870-2.125) | .18 | 0.515 (0.361-0.734) | <.01 |
| Age at HSCT, y | ||||||||||
| 0-20 | 1 | 1 | 1 | 1 | — | — | ||||
| 21-40 | 1.373 (1.114-1.693) | <.01 | — | — | — | — | — | — | — | — |
| 41-60 | 1.481 (1.225-1.790) | <.01 | 1.398 (1.132-1.727) | <.01 | — | — | 1.677 (1.318-2.135) | <.01 | — | — |
| ≥61 | 1.906 (1.558-2.331) | <.01 | 1.690 (1.284-2.224) | <.01 | 1.927 (1.121-3.313) | 0 | 1.899 (1.417-2.545) | <.01 | — | — |
| Disease status at HSCT | ||||||||||
| CR1 | — | — | 1 | — | — | — | — | 1 | ||
| ≥CR2 | — | — | 1.174 (1.002-1.374) | .05 | — | — | — | — | 1.265 (1.051-1.524) | .01 |
| Donor source | ||||||||||
| BM | — | — | 1 | <.01 | — | — | — | — | — | — |
| PB | — | — | 1.339 (1.170-1.532) | — | — | — | — | — | — | |
| ECOG-PS | ||||||||||
| 0-2 | — | — | — | — | — | — | 1 | — | — | |
| 3-4 | — | — | — | — | — | — | 1.820 (1.338-2.476) | <.01 | — | — |
| HLA disparity | ||||||||||
| Match | 1 | — | — | — | — | — | — | — | — | |
| Mismatch† | 1.233 (1.003-1.515) | .046 | — | — | — | — | — | — | — | — |
| Sex | ||||||||||
| Male | — | — | 1 | — | — | 1 | — | — | ||
| Female | — | — | 0.832 (0.731-0.948) | <.01 | — | — | 0.777 (0.678-0.889) | <.01 | — | — |
| Variables . | CB . | MRD . | 1-MMRD . | MUD . | 1-MMUD . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Use of ATG* | ||||||||||
| ATG(−) | 1 | 1 | 1 | 1 | 1 | |||||
| ATG(+) | 1.458 (0.995-1.979) | .053 | 0.990 (0.530-1.851) | .95 | 0.915 (0.634-1.322) | .64 | 1.360 (0.870-2.125) | .18 | 0.515 (0.361-0.734) | <.01 |
| Age at HSCT, y | ||||||||||
| 0-20 | 1 | 1 | 1 | 1 | — | — | ||||
| 21-40 | 1.373 (1.114-1.693) | <.01 | — | — | — | — | — | — | — | — |
| 41-60 | 1.481 (1.225-1.790) | <.01 | 1.398 (1.132-1.727) | <.01 | — | — | 1.677 (1.318-2.135) | <.01 | — | — |
| ≥61 | 1.906 (1.558-2.331) | <.01 | 1.690 (1.284-2.224) | <.01 | 1.927 (1.121-3.313) | 0 | 1.899 (1.417-2.545) | <.01 | — | — |
| Disease status at HSCT | ||||||||||
| CR1 | — | — | 1 | — | — | — | — | 1 | ||
| ≥CR2 | — | — | 1.174 (1.002-1.374) | .05 | — | — | — | — | 1.265 (1.051-1.524) | .01 |
| Donor source | ||||||||||
| BM | — | — | 1 | <.01 | — | — | — | — | — | — |
| PB | — | — | 1.339 (1.170-1.532) | — | — | — | — | — | — | |
| ECOG-PS | ||||||||||
| 0-2 | — | — | — | — | — | — | 1 | — | — | |
| 3-4 | — | — | — | — | — | — | 1.820 (1.338-2.476) | <.01 | — | — |
| HLA disparity | ||||||||||
| Match | 1 | — | — | — | — | — | — | — | — | |
| Mismatch† | 1.233 (1.003-1.515) | .046 | — | — | — | — | — | — | — | — |
| Sex | ||||||||||
| Male | — | — | 1 | — | — | 1 | — | — | ||
| Female | — | — | 0.832 (0.731-0.948) | <.01 | — | — | 0.777 (0.678-0.889) | <.01 | — | — |