Multivariate analysis of the clinical impact of ATG in each donor type
| . | CB . | MRD . | 1-MMRD . | MUD . | 1-MMUD . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | HR (95% CI) . | P . | n . | HR (95% CI) . | P . | n . | HR (95% CI) . | P . | n . | HR (95% CI) . | P . | n . | HR (95% CI) . | P . | |
| Neutrophil engraftment | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 1.213 (0.833-1.765) | .31 | 18 | 0.919 (0.659-1.281) | .62 | 72 | 1.083 (0.802-1.462) | .60 | 33 | 0.946 (0.671-1.332) | .75 | 103 | 1.115 (0.920-1.351) | .27 |
| Platelet engraftment | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 0.987 (0.699-1.393) | .94 | 18 | 0.882 (0.502-1.549) | .66 | 72 | 1.087 (0.809-1.460) | .58 | 33 | 0.893 (0.570-1.400) | .62 | 103 | 0.898 (0.716-1.126) | .35 |
| Grades II to IV aGVHD | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 0.900 (0.543-1.494) | .68 | 18 | 0.163 (0.022-1.205) | .08 | 72 | 0.552 (0.352-0.863) | <.01 | 33 | 0.712 (0.368-1.378) | .31 | 103 | 0.576 (0.399-0.832) | <.01 |
| Extensive cGVHD | |||||||||||||||
| ATG(−) | 1627 | 1 | 1683 | 1 | 144 | 1 | 1591 | 1 | 774 | 1 | |||||
| ATG(+) | 41 | 0.455 (0.112-1.852) | .27 | 16 | 0.210 (0.029-1.502) | .12 | 62 | 0.517 (0.262-1.022) | .06 | 29 | 1.326 (0.589-2.983) | .50 | 93 | 0.460 (0.244-0.869) | .02 |
| NRM | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 1.608 (1.048-2.468) | .03 | 18 | 1.161 (0.271-4.966) | .84 | 72 | 0.764 (0.383-1.525) | .45 | 33 | 1.475 (0.702-3.101) | .30 | 103 | 0.545 (0.315-0.944) | .03 |
| RI | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 1.023 (0.527-1.988) | .95 | 18 | 2.026 (0.968-4.242) | .06 | 72 | 1.216 (0.579-2.555) | .61 | 33 | 1.206 (0.572-2.545) | .62 | 103 | 0.773 (0.410-1.459) | .43 |
| OS | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 1.403 (0.991-2.145) | .054 | 18 | 2.092 (1.033-4.237) | .04 | 72 | 0.867 (0.526-1.430) | .58 | 33 | 1.358 (0.763-2.417) | .30 | 103 | 0.673 (0.438-1.033) | .07 |
| . | CB . | MRD . | 1-MMRD . | MUD . | 1-MMUD . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | HR (95% CI) . | P . | n . | HR (95% CI) . | P . | n . | HR (95% CI) . | P . | n . | HR (95% CI) . | P . | n . | HR (95% CI) . | P . | |
| Neutrophil engraftment | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 1.213 (0.833-1.765) | .31 | 18 | 0.919 (0.659-1.281) | .62 | 72 | 1.083 (0.802-1.462) | .60 | 33 | 0.946 (0.671-1.332) | .75 | 103 | 1.115 (0.920-1.351) | .27 |
| Platelet engraftment | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 0.987 (0.699-1.393) | .94 | 18 | 0.882 (0.502-1.549) | .66 | 72 | 1.087 (0.809-1.460) | .58 | 33 | 0.893 (0.570-1.400) | .62 | 103 | 0.898 (0.716-1.126) | .35 |
| Grades II to IV aGVHD | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 0.900 (0.543-1.494) | .68 | 18 | 0.163 (0.022-1.205) | .08 | 72 | 0.552 (0.352-0.863) | <.01 | 33 | 0.712 (0.368-1.378) | .31 | 103 | 0.576 (0.399-0.832) | <.01 |
| Extensive cGVHD | |||||||||||||||
| ATG(−) | 1627 | 1 | 1683 | 1 | 144 | 1 | 1591 | 1 | 774 | 1 | |||||
| ATG(+) | 41 | 0.455 (0.112-1.852) | .27 | 16 | 0.210 (0.029-1.502) | .12 | 62 | 0.517 (0.262-1.022) | .06 | 29 | 1.326 (0.589-2.983) | .50 | 93 | 0.460 (0.244-0.869) | .02 |
| NRM | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 1.608 (1.048-2.468) | .03 | 18 | 1.161 (0.271-4.966) | .84 | 72 | 0.764 (0.383-1.525) | .45 | 33 | 1.475 (0.702-3.101) | .30 | 103 | 0.545 (0.315-0.944) | .03 |
| RI | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 1.023 (0.527-1.988) | .95 | 18 | 2.026 (0.968-4.242) | .06 | 72 | 1.216 (0.579-2.555) | .61 | 33 | 1.206 (0.572-2.545) | .62 | 103 | 0.773 (0.410-1.459) | .43 |
| OS | |||||||||||||||
| ATG(−) | 1862 | 1 | 1754 | 1 | 153 | 1 | 1709 | 1 | 860 | 1 | |||||
| ATG(+) | 53 | 1.403 (0.991-2.145) | .054 | 18 | 2.092 (1.033-4.237) | .04 | 72 | 0.867 (0.526-1.430) | .58 | 33 | 1.358 (0.763-2.417) | .30 | 103 | 0.673 (0.438-1.033) | .07 |
95% CI, 95% confidence interval.