Table 3. Operating characteristics of... | American Society of Hematology

Table 3.

Operating characteristics of the HEP score and 4Ts score by scorer experience

Model	AUC (95% CI)	P*	Cutoff	Sensitivity, % (95% CI)†	Specificity, % (95% CI)†	PPV, % (95% CI)†	NPV, % (95% CI)†
Attending physicians, 103 cases: HIT prevalence, 9.8%
HEP score	0.85 (0.74-0.96)	.85	3	100 (69.2-100)	40.9 (30.8-51.5)	15.4 (7.6-26.5)	100 (90.7-100)
4Ts	0.84 (0.74-0.94)	.85	4	100 (69.2-100)	43.5 (32.8-53.7)	15.9 (7.9-27.3)	100 (91.2-100)
Trainees, 189 cases: HIT prevalence, 18%
HEP score	0.80 (0.72-0.88)	.02	3	93.9 (79.8-99.3)	32.7 (25.4-40.7)	22.8 (16.0-30.8)	96.2 (87-99.5)
4Ts	0.72 (0.63-0.81)	.02	4	97.0 (84.2-99.9)	26.9 (20.1-34.6)	21.9 (15.5-29.5)	97.7 (87.7-99.9)

Model	AUC (95% CI)	P*	Cutoff	Sensitivity, % (95% CI)†	Specificity, % (95% CI)†	PPV, % (95% CI)†	NPV, % (95% CI)†
Attending physicians, 103 cases: HIT prevalence, 9.8%
HEP score	0.85 (0.74-0.96)	.85	3	100 (69.2-100)	40.9 (30.8-51.5)	15.4 (7.6-26.5)	100 (90.7-100)
4Ts	0.84 (0.74-0.94)	.85	4	100 (69.2-100)	43.5 (32.8-53.7)	15.9 (7.9-27.3)	100 (91.2-100)
Trainees, 189 cases: HIT prevalence, 18%
HEP score	0.80 (0.72-0.88)	.02	3	93.9 (79.8-99.3)	32.7 (25.4-40.7)	22.8 (16.0-30.8)	96.2 (87-99.5)
4Ts	0.72 (0.63-0.81)	.02	4	97.0 (84.2-99.9)	26.9 (20.1-34.6)	21.9 (15.5-29.5)	97.7 (87.7-99.9)

P value represents comparison of AUC using the method of DeLong et al.¹⁷

Exact binomial CIs displayed for sensitivity, specificity, PPV, and NPV.